Peppermint and Its Functionality: A Review

Masomeh, L; Mirjalili, Narges; Hassan, Reem; Hadi, Ali

doi:10.4172/1989-8436.100054

Cited by 23 publications

(15 citation statements)

References 17 publications

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“…23 Over recent years it has been demonstrated that both peppermint and its constituents induce antioxidant, antispasmodic, aromatic, antimicrobial, antibacterial, antiviral, anticarcinogenic, antitumorigenic, antiallergic, antiinflammatory, antifungal, antimutagenic, anticancer, antinauseant, antiseptic, antilipid peroxidation, antiheadache and antiobesity properties. 7,9,23,[26][27][28][29][30][31][32] Menthol is well absorbed by the oral route in rats (63% -74%) and rabbits (86% -90%). 33,34 and at ≤90%, this level is predictably much higher than that yielded by dermal absorption.…”

Section: Introductionmentioning

confidence: 99%

Toxicological effects ofMentha x piperita(peppermint): a review

et al. 2019

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Peppermint (Mentha x piperita L.) is a medicinal plant with significant pharmacological and therapeutic activities but side effects and detrimental impacts on health have been described. Herein, we studied the literature concerning the reported inherent toxicity of peppermint. Accordingly, we classified peppermint and its main constituents in acute, subacute, chronic, developmental toxicity and cytotoxicity studies. The review outcome revealed that peppermint and its main constituents (pulegone, menthone, menthol and menthofuran) exhibit some evidence of moderate toxicity. Peppermint and its menthol isomers possess no major innate mutagenic, genotoxic or embryotoxic properties. However, there is evidence that peppermint essential oil interacts appreciably with cytochrome P450 isoenzymes to reduce or prevent their activities in rat and human liver microsomes and this has a substantial clinical implication for drug metabolism. Moreover, peppermint essential oil is contraindicated in patients with bile duct obstruction, gall bladder inflammation and liver disorders. In patients with gastrointestinal reflux or hiatus hernia, its use should be exercised with caution because it may exacerbate the symptoms of gastrointestinal reflux.

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Section: Introductionmentioning

confidence: 99%

Toxicological effects ofMentha x piperita(peppermint): a review

et al. 2019

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“…When it comes to the most sensitive antibiotics, sensitivity rate of FOS, F, ETP, IMI, MEM, GN and AK were 89,58%; 91,66%; 93,75%; 93,75%; 94,79%; 83,33%; 84,37% respectively. Some researchers have reported sensitive rate FOS from 100% to 86% to E. coli in clinical samples (Ayub et al, 2016;Lawhale and Naikwade., 2017;Wagle et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibility Profiles and Prevalence of ESBLS among Escherichia coli Isolates Recovered from Clinical Specimens in Different Services

Cebeci

Keskin

2019

Middle Black Sea Journal of Health Science

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Objective: A retrospective analysis of the widely used antibiotics all susceptibility testing results from Escherichia coli cultured from clinical specimens private hospital from (January 2016 to November 2018) was performed. Methods: The VITEK 2 Compact automated microbiology system is designed for automated rapid antimicrobial susceptibility testing and identification of clinically relevant bacteria. Minimum inhibitory concentration (MIC) results previously obtained in recent clinical isolates with well-defined in isolates with well-characterized resistance mechanisms with the microdilution method were re-interpreted for the susceptible, intermediate and resistant categories using the 2018 EUCAST breakpoints. Clinical samples are most commonly isolated from blood, sputum and urine samples. Results: Escherichia coli isolates were highly resistant to ampicillin, cefuroxime and cefixime 79,16%, 60,41% and 58,33% respectively. Resistance rate of ceftriaxon was showed in 52,08%. When we compared to resistance of trimethoprim/sulfamethoxazole, Escherichia coli isolates showed 51,04% resistance rate. When it comes to the most sensitive antibiotics, sensitivity rate of fosfomycin, nitrofurantoin, ertapenem, imipenem, meropenem, gentamicin, and amikacin were 89,58%; 91,66%; 93,75%; 93,75%; 94,79%; 83,33%; 84,37% respectively. Conclusion: Considering the antibiogram, fosfomycin, nitrofurantoin, ertapenem, imipenem, meropenem, gentamicin and amikacin should be preferred drugs for E. coli infection isolated from clinical samples.

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“…The oil contains 26 identified volatile compounds, most of which are oxygenated monoterpenes such as menthol and iso-menthone [ 2 , 39 ]. Others include limonene, cineole, menthofuran, menthyl acetate, isoeugenol, pulegone, and carvone [ 40 ]. Umezu et al, in 2012, determined the CNS stimulant activity of peppermint oil using a discrete shuttle-type conditioned avoidance task in mice [ 41 ].…”

Section: Therapeutic Benefits Of Essential Oilsmentioning

confidence: 99%

Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System

Soares

Bhattacharya²,

Chakrabarti

et al. 2021

Plants

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Essential oils (EOs) have been traditionally used as ancient remedies to treat many health disorders due to their enormous biological activities. As mainstream allopathic medication currently used for CNS disorders is associated with adverse effects, the search to obtain safer alternatives as compared to the currently marketed therapies is of tremendous significance. Research conducted suggests that concurrent utilization of allopathic medicines and EOs is synergistically beneficial. Due to their inability to show untoward effects, various scientists have tried to elucidate the pharmacological mechanisms by which these oils exert beneficial effects on the CNS. In this regard, our review aims to improve the understanding of EOs’ biological activity on the CNS and to highlight the significance of the utilization of EOs in neuronal disorders, thereby improving patient acceptability of EOs as therapeutic agents. Through data compilation from library searches and electronic databases such as PubMed, Google Scholar, etc., recent preclinical and clinical data, routes of administration, and the required or maximal dosage for the observation of beneficial effects are addressed. We have also highlighted the challenges that require attention for further improving patient compliance, research gaps, and the development of EO-based nanomedicine for targeted therapy and pharmacotherapy.

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Peppermint and Its Functionality: A Review

Cited by 23 publications

References 17 publications

Toxicological effects ofMentha x piperita(peppermint): a review

Toxicological effects ofMentha x piperita(peppermint): a review

Antimicrobial Susceptibility Profiles and Prevalence of ESBLS among Escherichia coli Isolates Recovered from Clinical Specimens in Different Services

Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System

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