Peppermint oil in irritable bowel syndrome

Grigoleit, H.-G.; Grigoleit, P.

doi:10.1016/j.phymed.2004.10.005

Cited by 99 publications

(47 citation statements)

References 12 publications

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“…Former studies have suggested peppermint oil as a possible treatment for IBS symptoms [18,21]. In one randomized placebo-controlled clinical study, a 4-week treatment with Colpermin improved the overall abdominal symptoms in patients with IBS [19].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

et al. 2009

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Herbal remedies, particularly peppermint, have been reported to be helpful in controlling symptoms of irritable bowel syndrome (IBS). We conducted a randomized double-blind placebo-controlled study on 90 outpatients with IBS. Subjects took one capsule of enteric-coated, delayed-release peppermint oil (Colpermin) or placebo three times daily for 8 weeks. We visited patients after the first, fourth, and eighth weeks and evaluated their symptoms and quality of life. The number of subjects free from abdominal pain or discomfort changed from 0 at week 0 to 14 at week 8 in the Colpermin group and from 0 to 6 in controls (P < 0.001). The severity of abdominal pain was also reduced significantly in the Colpermin group as compared to controls. Furthermore, Colpermin significantly improved the quality of life. There was no significant adverse reaction. Colpermin is effective and safe as a therapeutic agent in patients with IBS suffering from abdominal pain or discomfort.

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Section: Discussionmentioning

confidence: 99%

“…This finding has led medical researchers to investigate the effectiveness of peppermint oil in IBS treatment [16,17]. Previous studies have suggested that an enteric-coated peppermint-oil formulation (Colpermin) might be helpful in relieving some symptoms of irritable bowel syndrome [18,19].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

et al. 2009

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“…As the general success; the average rate of the answers for the mint oil was 58% (between 39-79%). 26 An antidepressant selective serotonin reuptake inhibitor citolapram is used by the incidents of IBS, it is observed that it is very effective on not only present complaints, but also on anxiety and depression. 27 In a double blinded-placebo controlled study; cyproheptadin which was 5-HT2 receptor antagonist was succeeded 86 percent of the incidents.…”

Section: Treatmentmentioning

confidence: 99%

Irritable Bowel Syndrome in Childhood: Review

Gökçe¹,

Karakoyun²,

Yağcı³

et al. 2015

Turkiye Klinikleri J Pediatr

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A AB BS S T TR RA AC CT T Irritable bowel syndrome (IBS), is also known spastic colon, is one of the functional bowel diseases. Etiology of IBS is unknown and is associated with symptoms such as diarrhea and constipation. It usually affects both adults and adolescents. Functional bowel differences, disordered defecation habits and chronic abdominal pain, which is the most common of the symptoms, is due to bowel disorder. The frequency of the pain varies from patient to patient and is usually observed on the around umblicus but the pain observed another places on the abdomen. Etiopathogenesis hasn't become definite yet. The second important symptom is disturbed defecation and the changes in defecation pattern. Constipation and diarrhea often follow each other. Patients need to defecate after each meal. Dyspeptic symptoms; especially postprandial abdominal tenderness, abdominal discomfort, bloating, gas, indigestion, loss of appetite, nausea are also common in IBS. Diagnostic criteria which named Rome III criteria based on recurrent abdominal pain or discomfort following; improvement with defecation or change in frequency of stool or stool appearance. We report here; irritable bowel syndrome, diagnosis and treatment of it in children. K Ke ey y W Wo or rd ds s: : Child; irritable bowel syndrome Ö ÖZ ZE ET T İrritabl barsak sendromu (İBS) spastik kolon olarak da bilinen; fonksiyonel barsak hastalık-larından biridir. Etiyolojisi tam kesinleşmemiştir ve daha çok konstipasyon ve ishal gibi semptomlar ile karakterize bir hastalıktır. Genelde adolesan ve erişkinleri etkilemektedir. Organik bir neden olmaksızın barsaklarda fonksiyon değişiklikleri-dışkılama düzenindeki değişiklikler ve kronik karın ağrısı başlıca semptomlardır. Karın ağrısı; şiddeti, sıklığı hastadan hastaya değişiklik gösteren ve emosyonel stres, soğuk, bazı yiyecekler, bazı ilaçlarla şiddeti artan özelliktedir. Karın ağrısı genellikle göbek çevresinde olmakla birlikte birçok hastada farklı yerlerde de olabilmektedir. Etiyolojisi henüz netleştirilememiştir. Karın ağrısı dışında dışkılama rahatsızlıkları ve dışkılama düzenindeki değişiklikler ikinci önemli semptomdur. Çoğu kez konstipasyon ve ishal hali birbirini izler. Hastalar her yemekten sonra defekasyon ihtiyacı duyarlar. Dispeptik yakınmalar; özellikle postprandial karın gerginliği, karın rahatsızlığı, karın şişliği, gaz, hazımsızlık, geğirme, iştahsızlık, bulantı da İBS'de sık görülen yakınmalardır. Tanısında detaylı anamnez ve fizik bakı önemlidir. Uzun süredir devam eden karın ağrısı, ishal, konstipasyon dönemlerinin birbirini takip etmesi, hasta görünümün olmaması tanıda önemlidir. Son yirmi yıl içinde İBS tanısında kolaylık sağlayan bazı kriterler ortaya sürülmüştür. Karın ağrısı ya da karında rahatsızlık hissi ile bu duruma eşlik eden dışkılama düzenindeki değişiklikler ve dışkının görünüm değişiklikleri IBS tanısında Rome III kriterleri olarak kullanılmaktadır. Bu derlemede İBS'nin çocuklarda semptomları, tanısal yöntemleri ve tedavi yaklaşımları anlatılmaktadır.

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“…However, it is as yet uncertain how these effects are linked to the clinical efficacy. Peppermint oil is considered to be of value in patients with IBS [32] , even though this is not undisputed [33] . In patients with FD, there is one study that demonstrated efficacy of a peppermint/caraway oil combination in a randomized, placebo-controlled trial [34] .…”

Section: Herbal Medicinesmentioning

confidence: 99%

Failed Therapy and Directions for the Future in Dyspepsia

Holtmann¹,

Gapasin²

2008

Dig Dis

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Functional gastrointestinal disorders including functional dyspepsia are highly prevalent. Their clinical course is benign without disease-associated mortality. On the other hand, the impact can be substantial for the affected patients with regard to the decrease of quality of life, and for society with regard to the economical implications. Functional dyspepsia is a clinical syndrome with various underlying pathophysiologies. Thus, it is understandable that there is no single cure available. Reassurance by ruling out relevant differential diagnoses, explanation, and general advice with regard to the underlying causes and dietary and life-style measures are important components of the management of these patients. Well established medical treatments include Helicobacter pylori eradication, acid inhibitory agents and prokinetics. The overall gain over placebo ranges from less than 5% for H. pylori eradication to 15% for antisecretory agents and prokinetics. Thus, even considering a substantial proportion of patients with spontaneous remissions (usually addressed as placebo response in clinical trials), there are 20 to 40% of patients who do not respond properly to these measures. In these patients, other treatment modalities need to be considered. These second- or third-line measures include herbal medicines and psychotropic agents. Some of the herbal preparations have been well studied in controlled clinical trials with sufficient scientific evidence to assume efficacy. Psychotropic drugs on the other hand have, as yet, not been specifically tested in functional dyspepsia. Medications such as clonidine, buspirone or octreotide can be helpful in few selected patients. However, a very careful assessment of potential risks and benefits needs to be undertaken on a case-by-case basis. Other evidence-based measures include psychological interventions such as psychotherapy and hypnotherapy.

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Peppermint oil in irritable bowel syndrome

Cited by 99 publications

References 12 publications

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

The Effect of Enteric-Coated, Delayed-Release Peppermint Oil on Irritable Bowel Syndrome

Irritable Bowel Syndrome in Childhood: Review

Failed Therapy and Directions for the Future in Dyspepsia

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