Peptic ulcer and gastritis in uraemia, with particular reference to the effect of <i>Helicobacter pylori</i> infection

Kang, Jin Yong; Ho, Khek Yu; Yeoh, Khay-Guan; Guan, R; Wee, Aileen; Lee, E; Lye, Wai Choong; Leong, S. O.; Tan, Chorh Chuan

doi:10.1046/j.1440-1746.1999.01947.x

Cited by 42 publications

(43 citation statements)

References 32 publications

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“…Our study showed that patients with CKD and a history of UGIB had a 2-fold higher risk of UGIB. In addition, H. pylori infection has been associated with a higher risk of UGIB (23,24), and H. pylori eradication therapy decreases the risk of recurrent UGIB (25). Forty-two (1.4%) patients were receiving H. pylori eradication therapy; this therapy did not significantly affect UGIB risk.…”

Section: Discussionmentioning

confidence: 99%

Upper Gastrointestinal Bleeding in Patients with CKD

Liang

Wang

Kuo

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Patients with CKD receiving maintenance dialysis are at risk for upper gastrointestinal bleeding. However, the risk of upper gastrointestinal bleeding in patients with early CKD who are not receiving dialysis is unknown. The hypothesis was that their risk of upper gastrointestinal bleeding is negatively linked to renal function. To test this hypothesis, the association between eGFR and risk of upper gastrointestinal bleeding in patients with stages 3-5 CKD who were not receiving dialysis was analyzed. Results In total, 2968 patients with stages 3-5 CKD who were not receiving dialysis were followed for a median of 1.9 years. The incidence of upper gastrointestinal bleeding per 100 patient-years was 3.7 (95% confidence interval, 3.5 to 3.9) in patients with stage 3 CKD, 5.0 (95% confidence interval, 4.8 to 5.3) in patients with stage 4 CKD, and 13.9 (95% confidence interval, 13.1 to 14.8) in patients with stage 5 CKD. Higher eGFR was associated with a lower risk of upper gastrointestinal bleeding (P=0.03), with a subdistribution hazard ratio of 0.93 (95% confidence interval, 0.87 to 0.99) for every 5 ml/min per 1.73 m 2 higher eGFR. A history of upper gastrointestinal bleeding (P,0.001) and lower serum albumin (P=0.004) were independently associated with higher upper gastrointestinal bleeding risk. ConclusionsIn patients with CKD who are not receiving dialysis, lower renal function is associated with higher risk for upper gastrointestinal bleeding. The risk is higher in patients with previous upper gastrointestinal bleeding history and low serum albumin.

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Section: Discussionmentioning

confidence: 99%

Upper Gastrointestinal Bleeding in Patients with CKD

Liang

Wang

Kuo

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Nonetheless, previous studies have shown that the prevalence of H. pylori infection in patients with uremia is not higher than in the general population 6,23 and that H. pylori infection is not a risk factor for ulcer or recurrent ulcer in uremic patients. 14,24 Third, although smoking and alcohol consumption are risk factors for peptic ulcers, information about these factors was not available in the National Health Insurance dataset.…”

Section: Limitationsmentioning

confidence: 99%

Incidence of bleeding from gastroduodenal ulcers in patients with end-stage renal disease receiving hemodialysis

Luo¹,

Leu²,

Huang³

et al. 2011

Canadian Medical Association Journal

102

104

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“…Studies on H. pylori infections in uremic patients have reported rates varying from 27% to 73.0% [12][13][14][15][16][17][18][19][20] . This variation may have been caused by small sample sizes, nonuniform duration of dialysis, and varying methodologies and enrollment criteria.…”

Section: H Pylori Prevalence Among Patients With End-stage Renal Dismentioning

confidence: 99%

“…pylori detection in patients with ESRD can be improved by performing the 13 C-urea breath test (UBT) after hemodialysis therapy and assessing the UBT with a cutoff excess 13CO2/12CO2 ratio value exceeding 5. However, the diagnostic efficacy of the UBT for patients with ESRD remains less accurate than that for dyspeptic patients without renal impairment.…”

Section: H Pylori Tests For Patients With End-stage Renal Diseasementioning

confidence: 99%

Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens

Chang¹,

Hu²

2015

WJGPT

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Peptic ulcer and gastritis in uraemia, with particular reference to the effect of Helicobacter pylori infection

Abstract: The prevalence of histological gastritis was lower in uraemic patients when compared with patients with functional dyspepsia and healthy volunteers. Peptic ulcers in uraemic subjects have different clinical characteristics from peptic ulcer in non-uraemic subjects.

Cited by 42 publications

References 32 publications

Upper Gastrointestinal Bleeding in Patients with CKD

Upper Gastrointestinal Bleeding in Patients with CKD

Incidence of bleeding from gastroduodenal ulcers in patients with end-stage renal disease receiving hemodialysis

Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens

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