Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Collatuzzo, Giulia; Alicandro, Gianfranco; Bertuccio, Paola; Pelucchi, Claudio; Bonzi, Rossella; Palli, Domenico; Ferraroni, Monica; Ye, Weimin; Plymoth, Amelie; Заридзе, Давид; Maximovich, Dmitry; Aragonés, Núria; Castaño‐Vinyals, Gemma; Vioque, Jesús; Hera, Manoli García de la; Zhang, Zuo‐Feng; Ji, Hu; López‐Carrillo, Lizbeth; López-Cervantes, Malaquı́as; Dalmartello, Michela; Mu, Lina; Ward, Mary H.; Rabkin, Charles S.; Yu, Guo‐Pei; Camargo, M. Constanza; Curado, María Paula; Lunet, Nuno; Negri, Eva; Vecchia, Carlo La; Boffetta, Paolo

doi:10.1136/jech-2022-219074

Cited by 9 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to commonality in risk factors, PUD is shown to mediate the carcinogenic impact of some of the established GC risk factors. Previous study by the SToP consortium revealed the mediation role for PUD and a number of risk factors in development of GC [37]. The PUD was responsible for mediating 36% of the effect of tobacco smoking on gastric carcinogenesis [37].…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Paragomi

Dabo

Pelucchi

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth’s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07–4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77–1.39). Conclusions. In the pooled analysis of 11 case–control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

show abstract

Section: Discussionmentioning

confidence: 96%

“…Previous study by the SToP consortium revealed the mediation role for PUD and a number of risk factors in development of GC [37]. The PUD was responsible for mediating 36% of the effect of tobacco smoking on gastric carcinogenesis [37].…”

Section: Discussionmentioning

confidence: 96%

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Paragomi

Dabo

Pelucchi

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is worthy of note that in the subgroup analysis of upper GI perforation, smoking history was indicated to be associated with prognosis. Smoking is a known risk factor for GI ulcers; previous studies have established a link between smoking and peptic ulcers ( 34 , 35 ). A study performed by Jha et al ( 36 ) suggested that smoking accounts for almost half of all male mortality in the lowest social strata of various countries.…”

Section: Discussionmentioning

confidence: 99%

Predictors of mortality in patients with isolated gastrointestinal perforation

Yan,

Wang,

Wei

et al. 2023

Exp Ther Med

View full text Add to dashboard Cite

Gastrointestinal (GI) perforation is common in the emergency department and has a high mortality rate. The present study aimed to identify risk factors for mortality in patients with GI perforation. The objective was to assess and prognosticate the surgical outcomes of patients, aiming to ascertain the efficacy of the procedure for individual patients. A retrospective cohort study of patients with GI perforation who underwent surgery in a public tertiary hospital in China from January 2012 to June 2022 was performed. Demographics, clinical characteristics, laboratory and imaging results, and outcomes were collected from electronic medical records. The primary outcome measure was in-hospital mortality, and patients were divided into survivor and non-survivor groups based on this measure. Univariate and multivariable logistic regression analyses were performed to obtain independent factors associated with mortality. A total of 529 patients with GI perforation were eligible for inclusion. The in-hospital mortality rate after emergency surgery was 10.59%. The median age of the patients was 60 years (interquartile range, 44-72 years). Multivariable logistic regression analysis indicated that age, shock on admission, elevated serum creatinine (sCr) and white blood cell (WBC) count <3.5x10 9 or >20x10 9 cells/l were predictors of in-hospital mortality. In conclusion, advanced age, shock on admission, elevated sCr levels and significantly abnormal WBC count are associated with higher in-hospital mortality following emergency laparotomy.

show abstract

“…Through a comprehensive literature search on various databases (PubMed/ MEDLINE, Embase, Institute for Scientific Information Web of Science, and the Cochrane Database of Systematic Reviews), we identified all meta-analyses, pooled analyses, and reviews on the association between cigarette smoking and cancer risk published up to October 12 2022. In particular, we identified 20 systematic reviews/metaanalyses [8][9][10][11][12][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] and 16 pooled analyses [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] on GC (Supplementary Fig. 1).…”

Section: Search Strategymentioning

confidence: 99%

Dose–response association between cigarette smoking and gastric cancer risk: a systematic review and meta-analysis

Rota,

Possenti,

Valsassina

et al. 2024

Gastric Cancer

View full text Add to dashboard Cite

This study aims at providing an accurate and up-to-date quantification of the dose-response association between cigarette smoking and gastric cancer (GC) risk, overall and by subsite. We conducted a systematic review and meta-analysis of casecontrol and cohort studies on the association between cigarette smoking and GC risk published up to January 2023. We estimated pooled relative risks (RR) of GC and its subsites according to smoking status, intensity, duration, and time since quitting. Among 271 eligible articles, 205 original studies were included in this meta-analysis. Compared with never smokers, the pooled RR for GC was 1.53 (95% confidence interval; CI 1.44-1.62; n = 92) for current and 1.30 (95% CI 1.23-1.37; n = 82) for former smokers. The RR for current compared with never smokers was 2.08 (95% CI 1.66-2.61; n = 21) for gastric cardia and 1.48 (95% CI 1.33-1.66; n = 8) for distal stomach cancer. GC risk nonlinearly increased with smoking intensity up to 20 cigarettes/day (RR:1.69; 95% CI 1.55-1.84) and levelled thereafter. GC risk significantly increased linearly with increasing smoking duration (RR: 1.31; 95% CI 1.25-1.37 for 20 years) and significantly decreased linearly with increasing time since quitting (RR: 0.65; 95% CI 0.44-0.95 for 30 years since cessation). The present meta-analysis confirms that cigarette smoking is an independent risk factor for GC, particularly for gastric cardia. GC risk increases with a low number of cigarettes up to 20 cigarettes/day and increases in a dose-dependent manner with smoking duration.

show abstract

Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Cited by 9 publications

References 49 publications

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Predictors of mortality in patients with isolated gastrointestinal perforation

Dose–response association between cigarette smoking and gastric cancer risk: a systematic review and meta-analysis

Contact Info

Product

Resources

About