Abstract:NSAID, low-dose ASA use, and H. pylori infection are three independent risk factors for the development of PUB, but there were differences in the interaction effect between low-dose ASA (no interaction) or NSAID (addition) use and H. pylori infection, which may have implications for clinical practice in prevention strategies.
“…NSAIDs, aspirin, and H. pylori infection are independent risk factors for peptic ulcer and peptic ulcer complications 45 46. A meta-analysis showed that NSAIDs use increases the risk of peptic ulcer in H. pylori -infected patients 45.…”
Section: Working Group 1: Indications/associationsmentioning
confidence: 99%
“…A meta-analysis showed that NSAIDs use increases the risk of peptic ulcer in H. pylori -infected patients 45. A recent epidemiological study has shown that H. pylori infection and NSAIDs use have additive effects on the risk of peptic ulcer bleeding 46. Another meta-analysis47 of five randomised clinical trials and additional studies reported more recently48 have shown that H. pylori eradication is associated with a reduced incidence of peptic ulcer in new users but not in chronic users.…”
Section: Working Group 1: Indications/associationsmentioning
“…NSAIDs, aspirin, and H. pylori infection are independent risk factors for peptic ulcer and peptic ulcer complications 45 46. A meta-analysis showed that NSAIDs use increases the risk of peptic ulcer in H. pylori -infected patients 45.…”
Section: Working Group 1: Indications/associationsmentioning
confidence: 99%
“…A meta-analysis showed that NSAIDs use increases the risk of peptic ulcer in H. pylori -infected patients 45. A recent epidemiological study has shown that H. pylori infection and NSAIDs use have additive effects on the risk of peptic ulcer bleeding 46. Another meta-analysis47 of five randomised clinical trials and additional studies reported more recently48 have shown that H. pylori eradication is associated with a reduced incidence of peptic ulcer in new users but not in chronic users.…”
Section: Working Group 1: Indications/associationsmentioning
“…Считается, что H. pylori, НПВП, аспирин являются независимы-ми факторами риска развития пептической язвы и ее осложнений [15]. Однако рассматривается и обсужда-ется также возможность аддитивного (взаимодополня-ющего) действия H. pylori и НПВП на риск развития язв и кровотечений [16]. Авторы консенсуса рекомендуют тестировать на H. рylori-инфекцию пациентов, при-нимающих НПВП и аспирин, с наличием в анамнезе пептической язвы, а также обязательно рекомендовать им прием ингибиторов протонной помпы и при выяв-лении бактерии -антихеликобактерную терапию.…”
Section: ключевые слова: H рYlori-инфекция; диагностика; лечение; прunclassified
“…We were not able to explore the role of Helicobacter pylori infection [17,30] or higher doses of NSAIDs [2,31] and multiple NSAID use [28], which are recognised causes of NSAID-associated GI complications as this information was not available for all patients in this study.…”
Section: Predictive Factors Of Upper Gi Adverse Eventsmentioning
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