Peptic Ulcer Disease and Neuroticism in the United States Adult Population

Goodwin, Renée D.; Stein, Murray B.

doi:10.1159/000067184

Cited by 39 publications

(29 citation statements)

References 20 publications

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“…Our finding also supports research reporting the prognostic importance of depressive symptoms: Depressive symptoms were predictive of similar symptoms 32 years later (Zonderman et al 1993) and similar results are reported by Westermeyer (1998). In contrast, our results do not support findings from studies reporting that personality traits are distinct predictors of objective health (Glazer et al 2002;Goodwin and Stein 2003;Goodwin and Friedman 2006), although it has been criticized that some associations between neuroticism and health result from reporting artefacts (Watson and Pennebaker 1989). On the other hand, our findings confirm results from other prospective studies questioning the over-rated role of openness and emotional reactivity as long-term predictors for adaptation and health in old age (Friedman 2000).…”

Section: Discussionsupporting

confidence: 67%

Personality and health in middle age as predictors for well-being and health in old age

et al. 2008

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In research literature, the question to what extent specific personality traits and health functioning in midlife can predict physical and psychological well-being in old age is still discussed controversially. The present study aims to shed light on this issue by using data from the Basel Longitudinal Study on Ageing. Structural equation modelling was performed in order to test the relation between personality dimensions, namely, self-preoccupation and emotional reactivity, as well as cardiovascular functioning (blood pressure) and medication intake (tranquilizer use) in middle age on psychological and physical well-being and health as assessed in old age 24 years later. Results show that high levels of self-preoccupation in middle age are negatively related to psychological and physical well-being in old age, but not to medical diagnoses. In addition, blood pressure and tranquilizer use in middle age predict physical well-being in old age; blood pressure is furthermore related to medical diagnoses. Our findings emphasize the importance for the adoption of a life-span approach and further interdisciplinary prospective studies in order to better predict pathways to well-being and health in old age.

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Section: Discussionsupporting

confidence: 67%

Personality and health in middle age as predictors for well-being and health in old age

et al. 2008

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“…Marital Status: Married Divorced/separated/widowed Never married 455 (79) 75 (13) 46 (8) 2643 (73) 681 (19) 305 (8) .003…”

Section: Discussionmentioning

confidence: 99%

Neuroticism, cognitive ability, and the metabolic syndrome: The Vietnam Experience Study

Phillips

Batty

Weiss

et al. 2010

Journal of Psychosomatic Research

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Objectives: To explore the association of neuroticism with the metabolic syndrome, separate components of the metabolic syndrome, and the number of components of metabolic syndrome an individual possesses. To examine the extent to which any associations are accounted for by socio-demographic factors, health behaviours, and cognitive ability. Method: Participants were 4,208 men drawn from the Vietnam Experience Study. From military archives, and a later telephone interview and psychological and medical examination, socio-demographic, health behaviour, cognitive ability, neuroticism, and health data were collected. Neuroticism and cognitive ability were assessed with standardised tests during the medical examination. Presence of the metabolic syndrome was based on: body mass index; fasting blood glucose or a diagnosis of diabetes; high blood pressure or taking antihypertensive medication; HDL cholesterol; and triglyceride levels. Results: Neuroticism was positively associated with the occurrence of the metabolic syndrome and several of its components in both age-, and socio-demographic- and health behaviour-adjusted analyses. Many associations were accounted for by individual difference in cognitive ability. Neuroticism was robustly associated with the number of components of the metabolic syndrome after adjustment. Conclusions: Individuals with higher neuroticism scores had a higher prevalence of the metabolic syndrome, and a larger number of its components. On the whole, differences in cognitive ability appeared to partially mediate, the relationship between neuroticism and the metabolic syndrome

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“…Numerous epidemiological studies show that personality traits are important risk factors for many psychiatric and non-psychiatric disorders (1)(2)(3)(4)(5)(6)(7)(8)(9). Personality traits are thought to be complex and determined largely by genetic factors (10).…”

Section: Introductionmentioning

confidence: 99%

A genome-wide linkage study of individuals with high scores on NEO personality traits

et al. 2011

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The NEO Five Factor Inventory divides human personality traits into five dimensions: neuroticism, extraversion, openness, conscientiousness and agreeableness. In this study, we sought to identify regions harboring genes with large effects on the five NEO personality traits by performing genome-wide linkage analysis of individuals scoring in the extremes of these traits (> 90 th percentile). Affected-only linkage analysis was performed using an Illumina 6K linkage array in a family-based study, the Erasmus Rucphen Family study (ERF). We subsequently determined whether distinct, segregating haplotypes found with linkage analysis were associated with the trait of interest in the population. Finally, a dense SNP genotyping array (Illumina 318K) was used to search for copy number variations (CNVs) in the associated regions. In the families with extreme phenotype scores, we found significant evidence of linkage for conscientiousness to 20p13 (rs1434789, LOD=5.86) and suggestive evidence of linkage (LOD > 2.8) for neuroticism to 19q, 21q and 22q, extraversion to 1p, 1q, 9p and12q, openness to 12q and 19q, and agreeableness to 2p, 6q, 17q and 21q. Further analysis determined haplotypes on 21q22 for neuroticism (p-values = 0.009, 0.007), on 17q24 for agreeableness (marginal pvalue = 0.018) and on 20p13 for conscientiousness (marginal p-values = 0.058, 0.038) segregating in families with large contributions to the LOD scores. No evidence for CNVs in any of the associated regions was found. Our findings imply that there may be genes with relatively large effects involved in personality traits, which may be identified with next generation sequencing techniques.

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Peptic Ulcer Disease and Neuroticism in the United States Adult Population

Cited by 39 publications

References 20 publications

Personality and health in middle age as predictors for well-being and health in old age

Personality and health in middle age as predictors for well-being and health in old age

Neuroticism, cognitive ability, and the metabolic syndrome: The Vietnam Experience Study

A genome-wide linkage study of individuals with high scores on NEO personality traits

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