Peptic ulcer in man. Part I. The ulcer problem

Bralow, S. P.; Spellberg, Mitchell A.; Kroll, Hannes; Necheles, H.

doi:10.1007/bf03002510

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of hyperacidity As mentioned above, despite prolific arguments and the lack of agreement about the role of acid in ulceration, the acid theory seemed at the time to be the most fruitful hypothesis in terms of possible treatment (Christie & Tansey, 2002, p. 20). Therefore, the primary focus for treatment centered on regulating gastric secretion, which was reflected in a widely popular dictum: 'no acid, no ulcer', coined by Karl Schwarz in 1910(Bralow et al, 1950.…”

Section: Factors That Played a Role In The Demise Of The Bacterial Hypothesismentioning

confidence: 99%

Rethinking the history of peptic ulcer disease and its relevance for network epistemology

Radomski

Šešelja

Naumann

2021

HPLS

View full text Add to dashboard Cite

The history of the research on peptic ulcer disease (PUD) is characterized by a premature abandonment of the bacterial hypothesis, which subsequently had its comeback, leading to the discovery of Helicobacter pylori—the major cause of the disease. In this paper we examine the received view on this case, according to which the primary reason for the abandonment of the bacterial hypothesis in the mid-twentieth century was a large-scale study by a prominent gastroenterologist Palmer, which suggested no bacteria could be found in the human stomach. To this end, we employ the method of digital textual analysis and study the literature on the etiology of PUD published in the decade prior to Palmer’s article. Our findings suggest that the bacterial hypothesis had already been abandoned before the publication of Palmer’s paper, which challenges the widely held view that his study played a crucial role in the development of this episode. In view of this result, we argue that the PUD case does not illustrate harmful effects of a high degree of information flow, as it has frequently been claimed in the literature on network epistemology. Moreover, we argue that alternative examples of harmful effects of a high degree of information flow may be hard to find in the history of science.

show abstract

Section: Factors That Played a Role In The Demise Of The Bacterial Hypothesismentioning

confidence: 99%

Rethinking the history of peptic ulcer disease and its relevance for network epistemology

Radomski

Šešelja

Naumann

2021

HPLS

View full text Add to dashboard Cite

show abstract

“…The role of hyperacidity As mentioned above, despite prolific arguments and the lack of agreement about the role of acid in ulceration, the acid theory seemed at the time to be the most fruitful hypothesis in terms of possible treatment (Christie and Tansey, 2002, p. 20). Therefore, the primary focus for treatment centered on regulating gastric secretion, which was reflected in a widely popular dictum: 'no acid, no ulcer', coined by Schwarz, 1910(Bralow et al, 1950.…”

Section: Factors That Played a Role In The Demise Of The Bacterial Hymentioning

confidence: 99%

Rethinking the History of Peptic Ulcer Disease: from digital textual analysis to declining research programs

Radomski

Šešelja

Naumann

2021

Preprint

View full text Add to dashboard Cite

The history of the research on peptic ulcer disease (PUD) is characterized by a premature abandonment of the bacterial hypothesis, which subsequently had its comeback, leading to the discovery of Helicobacter pylori the major cause of the disease. In this paper we examine the received view on this case, according to which the primary reason for the abandonment of the bacterial hypothesis of PUD in the mid-twentieth century was a large-scale study by a prominent gastroenterologist Palmer, which suggested no bacteria could be found in the human stomach. To this end, we employ the method of digital textual analysis and study the literature on the etiology of PUD published in the decade prior to Palmers article. Our ﬁndings suggest that the bacterial hypothesis of PUD had already been abandoned before the publication of Palmers paper, which challenges the widely held view that his study played a crucial role in the development of this episode. The paper makes two main contributions to the literature in integrated history and philosophy of science. First, we suggest that the received narrative on this historical episode, commonly used by philosophers, needs to be revised. Second, we introduce the notion of a declining research program and argue for its importance as a unit of socio-epistemic analysis, especially in combination with normative assessments, such as pursuitworthiness of scientiﬁc theories.

show abstract

?�ber die Testung s�urebindender und sekretionshemmender Substanzen mit Hilfe der intragastralen pH-Messung?

1954

View full text Add to dashboard Cite

Peptic ulcer in man. Part I. The ulcer problem

Cited by 7 publications

References 0 publications

Rethinking the history of peptic ulcer disease and its relevance for network epistemology

Rethinking the history of peptic ulcer disease and its relevance for network epistemology

Rethinking the History of Peptic Ulcer Disease: from digital textual analysis to declining research programs

?�ber die Testung s�urebindender und sekretionshemmender Substanzen mit Hilfe der intragastralen pH-Messung?

Contact Info

Product

Resources

About