2019
DOI: 10.1021/acsaelm.9b00476
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Peptide-Based Assemblies on Electrospun Polyamide-6/Chitosan Nanofibers for Detecting Visceral Leishmaniasis Antibodies

Abstract: An alternative label-free electrochemical immunosensor for the rapid detection of Leishmania braziliensis was developed by immobilizing a peptide-based probe of the promastigote surface antigen (PSA-38S) onto electrospun polyamide-6 (PA6)/chitosan nanofibers. An increase in chitosan content in the spinning solution leads to a decrease in the diameter of the formed fibers, whereas the differential scanning calorimetry (DSC) and X-ray diffraction (XRD) data showed a decrease in crystallinity upon increasing the … Show more

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Cited by 23 publications
(19 citation statements)
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“…where the recognition was based on an interaction between an epitope designed from the antigen and its specific antibody [74]. Polyamide 6 (PA6)/CS NFs were fabricated using the electrospinning technique (diameter in a range of 15-170 nm) and characterized with, i.a., SEM, XRD, and FT-IR.…”
Section: Liberato Et Al Presented An Immunosensor For the Detection Of Leischmania Braziliensismentioning
confidence: 99%
“…where the recognition was based on an interaction between an epitope designed from the antigen and its specific antibody [74]. Polyamide 6 (PA6)/CS NFs were fabricated using the electrospinning technique (diameter in a range of 15-170 nm) and characterized with, i.a., SEM, XRD, and FT-IR.…”
Section: Liberato Et Al Presented An Immunosensor For the Detection Of Leischmania Braziliensismentioning
confidence: 99%
“…Fibrin-specific peptides incorporated into Glycol-chitosan-coated AuNP were reported for CT-based imaging of cerebrovascular thrombi; peptide incorporated systems showed better stability and imaging capability . In another study, PSA-38S (sequence: NH 2 -CTSSA­PVARA­AGTG­DFTE­EQR­TNTL-COOH) electrospun with a polyamide-6/chitosan nanofibers-based biosensor was developed for the detection of visceral leishmaniasis antibodies . A novel bioassay incorporating NOF4, a synthetic peptide, immobilized on a porous chitosan foam via a histidine tag was developed for the capture-purification and detection of ochratoxin A, a natural carcinogenic mycotoxin, and other haptens .…”
Section: Peptide–chitosan Conjugatesmentioning
confidence: 99%
“…175 In another study, PSA-38S (sequence: NH 2 -CTSSAPVARAAGTGDFTEEQR-TNTL-COOH) electrospun with a polyamide-6/chitosan nanofibers-based biosensor was developed for the detection of visceral leishmaniasis antibodies. 176 A novel bioassay incorporating NOF4, a synthetic peptide, immobilized on a porous chitosan foam via a histidine tag was developed for the capture-purification and detection of ochratoxin A, a natural carcinogenic mycotoxin, and other haptens. 177 A radiolabeled peptides−chitosan conjugate has been explored for tumor diagnosis.…”
Section: Peptide−chitosan Conjugatesmentioning
confidence: 99%
“…The fiber morphology can be modified by altering the (PA6)/chitosan, thus changing the electrochemical characteristics. It is a favorable approach as it can differentiate negative and positive VL from human serum samples (Liberato et al, 2019).…”
Section: Protein/peptide-based Nanodiagnosticsmentioning
confidence: 99%