Peptide-based supramolecular assembly drugs toward cancer theranostics

Abstract

Introduction:Peptide-based supramolecular self-assembly has been demonstrated to be a flexible approach for the fabrication of programmable de novo nanodrugs by employing synergistic or reciprocal intermolecular non-covalent interactions. This class of nanomaterials holds significant promise for clinical translation, especially as cancer theranostics. Areas covered: In this review, we describe the concept of cancer theranostic drug assembly by employing non-covalent interactions. That is, molecular drugs are formulated into nanoscale and even microscale architectures by peptide-modulated self-assembly. A series of peptide-based supramolecular assembly drugs are discussed, with an emphasis on the relation between structural feature and theranostic performance. Expert opinion: Molecular design, manipulation of non-covalent interactions, and elucidation of structure-function relationships not only facilitate the implementation of supramolecular selfassembly principles in drug development, but also provide a new means for advancing anticancer nanostructured drugs toward clinical application.

Pore-engineered nanoarchitectonics for cancer therapy

“…For example, synthetic nanochaperone for peptide (SNCP) based on mesoporous silica nanoparticles are fabricated to mediate the apoptosis of cancer cells. After the immobilization of p53pep, the stabilization structure of the p53 peptide is induced from a random-coil structure to an α-helical structure 223 .…”

Applications of supramolecular assemblies in drug delivery and photodynamic therapy

“…Ordered nano or microstructures are formed by association of peptides with drug molecules in peptide-modulated self-assembly. 135 Peptide-modulated co-assembly with PSs is advantageous owing to the improved loading efficiency and particle stability, combined with the enhanced permeability and retention (EPR) effect. Bai and coworkers co-assembled a peptide (Fmoc-L 3 -OMe) with a porphyrin derivative ( m -THPP) by manipulating π–π stacking and hydrophobic interactions.…”

“…Ordered nano or microstructures are formed by association of peptides with drug molecules in peptide-modulated self-assembly. 135 Peptide-modulated co-assembly with PSs is advantageous owing to the improved loading efficiency and particle…”

Functionalized Fluorescent Nanostructures Generated from Self-Assembly of a Cationic Tripeptide Direct Cell-Selective Chemotherapeutic Drug Delivery

“…Nanoparticle-based drug delivery systems (NDDs) are of immense significance due to their competence to improve the bioactivity of drug molecules. − Compared with low-molecular-weight substrates, NDDs often displayed extended blood circulation half-life, improved penetration into tumor tissues, and capacity to release the loaded drugs directly into the cytoplasm in a controllable way . To date, a variety of nanoscale drug delivery transporters have been developed to meet the practical requirements of chemotherapeutic delivery, including synthetic organic nanomaterials ( e.g.…”