Peptide Binding to MHC Class II Molecules: Applications to Vaccine Design

Sinigaglia, Francesco; Kilgus, J.; Romagnoli, Paola; Guttinger, Maria; Pink, J. R. L.

doi:10.1007/978-3-642-83755-5_152

Progress in Immunology 1989

DOI: 10.1007/978-3-642-83755-5_152

|View full text |Cite

Peptide Binding to MHC Class II Molecules: Applications to Vaccine Design

Francesco Sinigaglia¹,

J. Kilgus²,

Paola Romagnoli³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1990

1994

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Rules for peptide binding to MHC class II molecules

Sinigaglia

Hammer

1994

APMIS

View full text Add to dashboard Cite

CD4+ T lymphocytes recognize peptide fragments of antigens that lie in the antigen binding pocket of class II major histocompatibility complex (MHC) molecules expressed on antigen‐presenting cells. Specificity of T cells is determined by structural features of both the MHC molecule and antigenic peptide. MHC class II amino acid sequences are highly polymorphic within a population, and correlate with individual differences in response to infectious agents, vaccines, tumour antigens, and autoantigens. In the last few years several important breakthroughs and technological advances have made it possible to clarify the role of polymorphism and the molecular events in peptide interaction with major histocompatibility complex (MHC) class II proteins. The X‐ray structural analysis of a MHC class II molecule together with the use of peptide libraries has permitted determination of the structural features of the complex between peptide antigen fragments and MHC class II proteins. The purpose of this article is to review our own studies and those of others on the requirements for peptide‐class II molecule interaction and discuss possible implications for active immune intervention.

show abstract

Rules for peptide binding to MHC class II molecules

Sinigaglia

Hammer

1994

APMIS

View full text Add to dashboard Cite

show abstract

Peptide-MHC Interaction: A Rational Approach to Vaccine Design

Romagnoli

Takács

Kilgus

et al. 1990

International Reviews of Immunology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Peptide Binding to MHC Class II Molecules: Applications to Vaccine Design

Cited by 2 publications

References 19 publications

Rules for peptide binding to MHC class II molecules

Rules for peptide binding to MHC class II molecules

Peptide-MHC Interaction: A Rational Approach to Vaccine Design

Contact Info

Product

Resources

About