Peptide dendrimer stabilized gold nanoparticles as sensors

Sreelekshmi, P J; Lakshmi, S.; Babu, G. Anandha; Devika, V; Rajeev, Niranjana; Sadanandan, Sandhya

doi:10.1016/j.matpr.2019.12.060

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Another important aspect that led to the development of the field of peptide-based sensors was related to the multiple possibilities of their immobilization process on the surfaces used in detection, whether it is electrodes, chips, piezoelements, or other surfaces involved in the detection process [ 21 , 22 , 42 ].…”

Section: Peptides In Sensors Designmentioning

confidence: 99%

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

et al. 2021

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Food safety and quality control pose serious issues to food industry and public health domains, in general, with direct effects on consumers. Any physical, chemical, or biological unexpected or unidentified food constituent may exhibit harmful effects on people and animals from mild to severe reactions. According to the World Health Organization (WHO), unsafe foodstuffs are especially dangerous for infants, young children, elderly, and chronic patients. It is imperative to continuously develop new technologies to detect foodborne pathogens and contaminants in order to aid the strengthening of healthcare and economic systems. In recent years, peptide-based sensors gained much attention in the field of food research as an alternative to immuno-, apta-, or DNA-based sensors. This review presents an overview of the electrochemical biosensors using peptides as molecular bio-recognition elements published mainly in the last decade, highlighting their possible application for rapid, non-destructive, and in situ analysis of food samples. Comparison with peptide-based optical and piezoelectrical sensors in terms of analytical performance is presented. Methods of foodstuffs pretreatment are also discussed.

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Section: Peptides In Sensors Designmentioning

confidence: 99%

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

et al. 2021

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“…the distribution of AMPs according to their deriving life kingdom is graphically represented. These peptides can be naturally produced by organisms as a mechanism of defense against pathogens and other threats in biological endogenous processes, but like other bioactive peptides, can also be obtained through fermentation, digestion, extraction, and hydrolysis[107][108][109]. Peptides with biological activity can also be synthesized based on a predicted biological function of the sequence and its characteristics, taking the structure of natural peptides as a model but not directly derived from them[110][111][112].…”

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confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Exploring the physicochemical and morphological properties of peptide‐hybridized dendrimers (DendriPeps) and their aggregates

Smith

Fabiani

Wang

et al. 2020

Journal of Polymer Science

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This article presents an integrated experimental and computational study of DendriPeps, a novel class of dendrimers featuring a polyamidoamine (PAMAM) backbone hybridized with peptide segments. Hydroxyl‐terminated Generation 2 (G.2) DendriPeps, comprising either four lysines (Lys) or four glutamic acids (Glu), and G.3 DendriPeps, comprising 8 Lys or 8 Glu, were first characterized in terms of hydrodynamic radius (Rh) and ζ‐potential in aqueous solution. Unlike PAMAM dendrimers, DendriPeps form aggregates with Rh between 60 and 980 nm and ζ‐potential between −130 and 80 mV despite their strong net charge. Upon application of shear, all aggregates disassemble into monomeric DendriPeps (Rh ~ 1–3 nm), but reform rapidly as shear is removed. Rheological characterization confirmed that DendriPep aggregates are disrupted by mild shear, but reform reversibly. Molecular dynamics simulations, informed by titrimetry, suggest that DendriPep aggregation derives from their multipolar structure and ability to rearrange the intermolecular/intramolecular pairing of titratable moieties at different pH values.

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Peptide dendrimer stabilized gold nanoparticles as sensors

Cited by 6 publications

References 23 publications

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Exploring the physicochemical and morphological properties of peptide‐hybridized dendrimers (DendriPeps) and their aggregates

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