Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Sinha, Nairiti; Langenstein, Matthew; Pochan, Darrin J.; Kloxin, Christopher J.; Saven, Jeffery G.

doi:10.1021/acs.chemrev.1c00712

Cited by 181 publications

(125 citation statements)

References 257 publications

Supporting

Mentioning

125

Contrasting

Order By: Relevance

“…Thus, therapeutic routes rely on identifying early-stage polymorphic oligomers and understanding their mechanisms of aggregation. Furthermore, the ability to experimentally probe the formation of peptide and protein aggregates is required both to facilitate the rational design of new protein biomaterials and to validate structural predictions from computational methods (16)(17)(18).…”

Section: Bodymentioning

confidence: 99%

Label-free detection of β-sheet polymorphism

Weeks

Buchanan

2022

Preprint

View full text Add to dashboard Cite

The ability to detect and characterize multiple secondary structures or polymorphs within peptide and protein aggregates is crucial to treatment and prevention of amyloidogenic diseases, production of novel biomaterials, and many other applications. Here we report a label-free method to distinguish multiple β-sheet configurations within a single peptide aggregate using two-dimensional infrared spectroscopy. By calculating the transition dipole strength (TDS) spectrum from the ratio of linear and two-dimensional signals, we can extract maximum TDS values which provide higher sensitivity to vibrational coupling, and thus specifics of protein structure, than vibrational frequency alone. TDS spectra of AcKFE8 aggregates reveal two distinct β-sheet structures within fibers that appear homogenous by other techniques. Furthermore, TDS spectra taken during early stages of aggregation show additional peaks that may indicate the presence of more weakly coupled β-sheet structures. These results demonstrate a unique and powerful spectroscopic method capable of distinguishing multiple oligomeric and polymorphic motifs throughout the aggregation using only native vibrational modes.

show abstract

Section: Bodymentioning

confidence: 99%

Label-free detection of β-sheet polymorphism

Weeks

Buchanan

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Molecular self-assembly is to make use of specific molecular recognition between molecules or between a fragment of a molecule and another fragment of a molecule to form a supermolecular structure through non-covalent interaction [ 16 , 17 , 18 ]. Self-assembly of molecules is generally driven by the spontaneous synergy of weak interactions based on numerous non-covalent bonds, such as hydrogen bonding, electrostatic interactions, and hydrophobic interactions [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

Wang

Yang

et al. 2022

Biosensors

View full text Add to dashboard Cite

Self-assembled biomaterials have been widely explored for real-time fluorescence imaging, imaging-guided surgery, and targeted therapy for tumors, etc. In particular, small molecule-based self-assembly has been established as a reliable strategy for cancer theranostics due to the merits of small-sized molecules, multiple functions, and ease of synthesis and modification. In this review, we first briefly introduce the supramolecular chemistry of small organic molecules in cancer theranostics. Then, we summarize and discuss advanced small molecule-based self-assembly for cancer theranostics based on three types, including peptides, amphiphilic molecules, and aggregation-induced emission luminogens. Finally, we conclude with a perspective on future developments of small molecule-based self-assembled biomaterials integrating diagnosis and therapy for biomedical applications. These applications highlight the opportunities arising from the rational design of small organic molecules with self-assembly properties for precision medicine.

show abstract

“…Nanomaterials formed by self-assembly of peptides have superior and unique physical and chemical properties, such as high mechanical strength, high thermal stability, high biocompatibility, simple preparation, and customizable functions [ 5 , 6 , 7 ]. These excellent properties provide peptides with a wide range of biological applications, such as biomedicine, bioimaging, photothermal diagnosis and treatment, biosensing, tissue engineering, and other applications [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Tailoring Peptide Self-Assembly and Formation of 2D Nanoribbons on Mica and HOPG Surface

Kong¹,

Liu²,

Yang³

et al. 2022

Materials

View full text Add to dashboard Cite

Studying the interactions between biomolecules and material interfaces play a crucial role in the designing and synthesizing of functional bionanomaterials with tailored structure and function. Previously, a lot of studies were performed on the self-assembly of peptides in solution through internal and external stimulations, which mediated the creation of peptide nanostructures from zero-dimension to three-dimension. In this study, we demonstrate the self-assembly behavior of the GNNQQNY peptide on the surface of mica and highly oriented pyrolytic graphite through tailoring the self-assembly conditions. Various factors, such as the type of dissolvent, peptide concentration, pH value, and evaporation period on the formation of peptide nanofibers and nanoribbons with single- and bi-directional arrays are investigated. It is found that the creation of peptide nanoribbons on both mica and HOPG can be achieved effectively through adjusting and optimizing the experimental parameters. Based on the obtained results, the self-assembly and formation mechanisms of peptide nanoribbons on both material interfaces are discussed. It is expected that the findings obtained in this study will inspire the design of motif-specific peptides with high binding affinity towards materials and mediate the green synthesis of peptide-based bionanomaterials with unique function and application potential.

show abstract

Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Cited by 181 publications

References 257 publications

Label-free detection of β-sheet polymorphism

Label-free detection of β-sheet polymorphism

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

Tailoring Peptide Self-Assembly and Formation of 2D Nanoribbons on Mica and HOPG Surface

Contact Info

Product

Resources

About