Peptide functionalized actively targeted MoS2 nanospheres for fluorescence imaging-guided controllable pH-responsive drug delivery and collaborative chemo/photodynamic therapy

Li, Yanyan; Dang, Guangyao; Younis, Muhammad Rizwan; Cao, Yutao; Wang, Kaiqi; Sun, Xiao; Zhang, Wenxian; Zou, Xianwen; Shen, Hui; An, Ruibing; Dong, Lifeng; Dong, Jian

doi:10.1016/j.jcis.2023.02.027

Cited by 13 publications

(7 citation statements)

References 40 publications

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“…[ 84 ] Although current studies indicate minimal biotoxicity of prepared chemodynamic nanoagents, future research should focus on reducing potential toxic effects while enhancing therapeutic efficacy. [ 43,85 ] Second, a deeper understanding of the operation mechanism of CDT is needed. [ 86 ] While Fenton‐like reactions for generating •OH have been extensively studied, the microenvironment of bacterial infections poses challenges to •OH production due to factors such as pH, GSH content, and H 2 O 2 levels.…”

Section: Discussionmentioning

confidence: 99%

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Zhang,

Guo,

Liu

et al. 2023

Exploration

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The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue to persist. Currently, antibiotic therapy remains the primary approach for tackling bacterial infections. However, the escalating rates of drug resistance coupled with the lag in the development of novel drugs have led to diminishing effectiveness of conventional treatments. Therefore, the development of nonantibiotic‐dependent therapeutic strategies has become imperative to impede the rise of bacterial resistance. The emergence of chemodynamic therapy (CDT) has opened up a new possibility due to the CDT can convert H2O2 into •OH via Fenton/Fenton‐like reaction for drug‐resistant bacterial treatment. However, the efficacy of CDT is limited by a variety of practical factors. To overcome this limitation, the sterilization efficiency of CDT can be enhanced by introducing the therapeutics with inherent antimicrobial capability. In addition, researchers have explored CDT‐based combined therapies to augment its antimicrobial effects and mitigate its potential toxic side effects toward normal tissues. This review examines the research progress of CDT in the antimicrobial field, explores various strategies to enhance CDT efficacy and presents the synergistic effects of CDT in combination with other modalities. And last, the current challenges faced by CDT and the future research directions are discussed.

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Section: Discussionmentioning

confidence: 99%

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Zhang,

Guo,

Liu

et al. 2023

Exploration

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“…These systems not only alleviate the systemic side effects caused by chemotherapeutic agents but also significantly enhance therapeutic efficacy, delivery, and cancer targeting (Table 2). This sub-section reviews two main peptidetargeted drug delivery systems for cancer therapy applications: peptide-drug conjugates and peptide-conjugated nanoparticles [50,51]. Sv peptide Gold Nanoclusters Refractory lymphomas [63] Abbreviations are as follows: (TTP): tumor targeting peptide, and (CPP): cell penetrating peptide.…”

Section: Peptide-mediated Targeted Drug Delivery System For Tumor Tre...mentioning

confidence: 99%

Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy

Yan,

Na,

Liu

et al. 2024

Pharmaceutics

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Traditional tumor treatments have the drawback of harming both tumor cells and normal cells, leading to significant systemic toxic side effects. As a result, there is a pressing need for targeted drug delivery methods that can specifically target cells or tissues. Currently, researchers have made significant progress in developing targeted drug delivery systems for tumor therapy using various targeting ligands. This review aims to summarize recent advancements in targeted drug delivery systems for tumor therapy, focusing on different targeting ligands such as folic acid, carbohydrates, peptides, aptamers, and antibodies. The review also discusses the advantages, challenges, and future prospects of these targeted drug delivery systems.

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“…This can aid in the optimization of treatment procedures and give crucial information on the efficacy of the therapy. [38][39][40][41][42] By inhibiting the interaction between integrins and their ligands, RGD peptides can be utilized alone to limit tumor development and angiogenesis. This has the potential to alter signaling pathways involved in cancer cell survival, migration, and invasion.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, RGD peptides can be combined with imaging agents to allow for real‐time monitoring of drug distribution and treatment response. This can aid in the optimization of treatment procedures and give crucial information on the efficacy of the therapy 38–42 …”

Section: Introductionmentioning

confidence: 99%

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RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

Javid,

Oryani,

Rezagholinejad

et al. 2024

Cancer Medicine

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RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing adverse effects on healthy tissues. RGD‐functionalized drug carriers are a viable option for cancer therapy as this focused approach has demonstrated promise in the future. Writing a review on the RGD peptide can significantly influence how drugs are developed in the future by improving our understanding of the peptide, finding knowledge gaps, fostering innovation, and making drug design easier.

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Peptide functionalized actively targeted MoS2 nanospheres for fluorescence imaging-guided controllable pH-responsive drug delivery and collaborative chemo/photodynamic therapy

Cited by 13 publications

References 40 publications

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

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