Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release

Li, Bing; Criado‐Gonzalez, Miryam; Adam, Alexandre; Bizeau, Joëlle; Mélart, Christophe; Carvalho, Alain; Bégin, Dominique; Jierry, Loı̈c; Mertz, Damien

doi:10.1021/acsanm.1c03959

Cited by 18 publications

(11 citation statements)

References 35 publications

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“…As a biosensing material, hydrogels prepared by enzymatic methods have the advantages of high sensitivity, strong specificity, and low detection limits. , These hydrogels were the earliest commercialized biosensor, and they have been used for the detection and analysis of multiple components. The development of cross-linking enzymes provides sensors with new materials and methods, and it will likely bring major changes to the field of biosensors. − As shown in Figure d, the hydrogel prepared by the enzymatic method was applied to the biosensors. − Studies have reported that a new type of dienzyme (lagen peroxidase and glucose oxidase)/poly(amino) sulfonate hydrogel sensor could determine lactic acid levels, and the sensor responded quickly (2 s) with a short recovery time (2 min). The total test time of this sensor was 4 min, which was faster than the commercial lactic acid detection, which typically requires up to 10 min …”

Section: Applications Of Enzyme-prepared Hydrogelsmentioning

confidence: 99%

A Review of the Mechanism, Properties, and Applications of Hydrogels Prepared by Enzymatic Cross-linking

Liu

2023

J. Agric. Food Chem.

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Hydrogels, as biological materials, are widely used in food, tissue engineering, and biomedical applications. Nevertheless, many issues remain in the preparation of hydrogels by physical and chemical methods, such as low bioaffinity, weak mechanical properties, and unstable structures, which also limit their applications in other fields. However, the enzymatic cross-linking method has the advantages of high catalytic efficiency, mild reaction conditions, and the presence of nontoxic substances. In this review, we evaluated the chemical, physical, and biological methods of preparing hydrogels and introduced three common cross-linking enzymes and their principles for preparing hydrogels. This review introduced the applications and properties of hydrogels prepared by the enzymatic method and also provided some suggestions regarding the current situation and future development of hydrogels prepared by enzymatic cross-linking.

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Section: Applications Of Enzyme-prepared Hydrogelsmentioning

confidence: 99%

A Review of the Mechanism, Properties, and Applications of Hydrogels Prepared by Enzymatic Cross-linking

Liu

2023

J. Agric. Food Chem.

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“…Several parameters need to be taken into account in order to obtain the requisite therapeutic effect which is necessarily monitored throughout the course of different stages of design [52] . Furthermore, the hydrophilicity or hydrophobicity of drugs, the passage, and the biodegradability of drugs tend to alter the interactions amongst the drug components which serves as one of the several factors [53–56] . The challenge lies in systematic monitoring of the two: the rate at which the drug release occurs and the biodegradation; making sure both circulate systematically at full capacity.…”

Section: Drug Loading and Drug Releasementioning

confidence: 99%

Stimuli‐Responsive and Multifunctional Nanogels in Drug Delivery

Ashwani,

Gopika,

Arun Krishna

et al. 2023

Chemistry & Biodiversity

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Nanogels represent promising drug delivery systems in the biomedical field, designed to overcome challenges associated with standard treatment approaches. Stimuli‐responsive nanogels, often referred to as intelligent materials, have garnered significant attention for their potential to enhance control over properties such as drug release and targeting. Furthermore, researchers have recently explored the application of nanogels in diverse sectors beyond biomedicine including sensing materials, catalysts, or adsorbents for environmental applications. However, to fully harness their potential as practical delivery systems, further research is required to better understand their pharmacokinetic behaviour, interactions between nanogels and bio distributions, as well as toxicities. One promising future application of stimuli‐responsive multifunctional nanogels is their use as delivery agents in cancer treatment, offering an alternative to overcome the challenges with conventional approaches. This review discusses various synthetic methods employed in developing nanogels as efficient carriers for drug delivery in cancer treatment. The investigations explore, the key aspects of nanogels, including their multifunctionality and stimuli‐responsive properties, as well as associated toxicity concerns. The discussions presented herein aim to provide the readers a comprehensive understanding of the potential of nanogels as smart drug delivery systems in the context of cancer therapy.

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“…Driven by noncovalent interactions, peptide self-assembly has received considerable attention for its wide biomedical applications including cancer and bacterial therapy, − tissue engineering, − immune modulation, , and drug delivery. − In this work, we utilized a de novo designed self-assembling peptide to construct a bacterium trapping system with high strain selectivity. As shown in Figure , the designed molecule N-K10 contains a binding domain, a linker, and a self-assembling motif.…”

Section: Introductionmentioning

confidence: 99%

Surface-Induced Peptide Nanofibers for Selective Bacteria Trapping

Zhu

Chen

et al. 2023

ACS Appl. Nano Mater.

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The abuse of antibiotics has led to the emergence of various drug-resistant bacterial strains that threaten human health. Other than a continuous screen for antibiotics, alternative strategies need to be adopted to inhibit bacterial invasion. Herein, we de novo designed a self-assembling peptide that contains a bacteria-binding domain, a linker, and a self-assembly motif. This peptide could specifically bind with a surface protein on Staphylococcus aureus, subsequently self-assemble to form nanofibers, and selectively engulf and trap the bacteria. Thus, these trapped bacteria lack the ability to invade host cells and are unable to form a biofilm. More importantly, the designed peptide is nontoxic to human cells. Such a “trap but not kill” strategy could serve as an alternative to conventional antibiotics and shows great potential for treating bacteria.

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Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release

Cited by 18 publications

References 35 publications

A Review of the Mechanism, Properties, and Applications of Hydrogels Prepared by Enzymatic Cross-linking

A Review of the Mechanism, Properties, and Applications of Hydrogels Prepared by Enzymatic Cross-linking

Stimuli‐Responsive and Multifunctional Nanogels in Drug Delivery

Surface-Induced Peptide Nanofibers for Selective Bacteria Trapping

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