Peptide-Modified Biopolymers for Biomedical Applications

Hersh, Jessica; Broyles, David; Capcha, José Manuel Cóndor; Dikici, Emre; Daunert, Sylvia; Deo, Sapna K.

doi:10.1021/acsabm.0c01145

Cited by 18 publications

(11 citation statements)

References 195 publications

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“…These switchable peptides have wide applications in tissue engineering as “smart materials” . In recent years, several important concise reviews on peptides and their biomedical applications have unveiled the power of peptides. − Therefore, in this article, we are discussing only a few representative applications of peptides in the biomedical field which has evolved significantly over the past years.…”

Section: Peptides In Biomedical Applicationsmentioning

confidence: 99%

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

et al. 2021

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Peptides are signaling epitopes that control many vital biological events. Increased specificity, synthetic feasibility with concomitant lack of toxicity, and immunogenicity make this emerging class of biomolecules suitable for different applications including therapeutics, diagnostics, and biomedical engineering. Further, chitosan, a naturally occurring linear polymer composed of D-glucosamine and N-acetyl-D-glucosamine units, possesses anti-microbial, muco-adhesive, and hemostatic properties along with excellent biocompatibility. As a result, chitosan finds application in drug/gene delivery, tissue engineering, and bioimaging. Despite these applications, chitosan demonstrates limited cell adhesion and lacks biosignaling. Therefore, peptide−chitosan hybrids have emerged as a new class of biomaterial with improved biosignaling properties and cell adhesion properties. As a result, recent studies encompass increased application of peptide−chitosan hybrids as composites or conjugates in drug delivery, cell therapy, and tissue engineering and as anti-microbial material. This review discusses the recent investigations involving chitosan−peptide materials and uncovers various aspects of these interesting hybrid materials for biomedical applications.

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Section: Peptides In Biomedical Applicationsmentioning

confidence: 99%

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

et al. 2021

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“…Thiol reactions provide rapid and controllable reaction kinetics and are highly selective because of the low abundance of cysteine residues in the peptides. [13] However, there are problems related to using thiolmaleimide reactions in vivo because in many antibody-drug conjugates (ADCs), thiosuccinimide bonds undergo maleimide elimination, resulting in the loss of drug in the ADCs and a reduction in ADCmediated delivery efficacy. [14] Ring-opening hydrolysis of the succinimide moiety stabilizes the drug linker, and this process is accelerated by electron-withdrawing N-substituents in the moiety.…”

Section: Peptide Conjugation Chemistrymentioning

confidence: 99%

Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics

et al. 2021

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Armed with the useful properties of small molecules and proteins, peptides hold the potential to be utilized in almost all biomedical research fields. However, the clinical application of peptides has been limited due to their intrinsic drawbacks, such as poor plasma stability and low target binding affinity. The conjugation of peptides to biological, organic (nonbiological), and inorganic materials has recently emerged as a promising strategy to address these problems. Hence, in this article, we provide an overview of the successful outcomes of using peptide-bio/organic/inorganic conjugates in various biomedical applications, including the diagnosis and treatment of diseases.

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“… 19 , 20 The nanoparticles modified with functional peptides can increase biocompatibility, cellular interactions, and receptor targeting. 21 …”

Section: Introductionmentioning

confidence: 99%

TAT&RGD Peptide-Modified Naringin-Loaded Lipid Nanoparticles Promote the Osteogenic Differentiation of Human Dental Pulp Stem Cells

Zheng¹,

Chu²,

Gao³

et al. 2022

IJN

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Background Naringin is a naturally occurring flavanone that promotes osteogenesis. Owing to the high lipophilicity, poor in vivo bioavailability, and extensive metabolic alteration upon administration, the clinical efficacy of naringin is understudied. Additionally, information on the molecular mechanism by which it promotes osteogenesis is limited. Methods In this study, we prepared TAT & RGD peptide-modified naringin-loaded nanoparticles (TAT-RGD-NAR-NPs), evaluated their potency on the osteogenic differentiation of human dental pulp stem cells (hDPSCs), and studied its mechanism of action through metabolomic analysis. Results The particle size and zeta potential of TAT-RGD-NAR-NPs were 160.70±2.05 mm and –20.77±0.47mV, respectively. The result of cell uptake assay showed that TAT-RGD-NAR-NPs could effectively enter hDPSCs. TAT-RGD-NAR-NPs had a more significant effect on cell proliferation and osteogenic differentiation promotion. Furthermore, in metabolomic analysis, naringin particles showed a strong influence on the glycerophospholipid metabolism pathway of hDPSCs. Specifically, it upregulated the expression of PLA2G3 and PLA2G1B (two isozymes of phospholipase A2, PLA2), increased the biosynthesis of lysophosphatidic acid (LPA). Conclusion These results suggested that TAT-RGD-NPs might be used for transporting naringin to hDPSCs for modulating stem cell osteogenic differentiation. The metabolomic analysis was used for the first time to elucidate the mechanism by which naringin promotes hDPSCs osteogenesis by upregulating PLA2G3 and PLA2G1B.

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Peptide-Modified Biopolymers for Biomedical Applications

Cited by 18 publications

References 195 publications

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics

TAT&RGD Peptide-Modified Naringin-Loaded Lipid Nanoparticles Promote the Osteogenic Differentiation of Human Dental Pulp Stem Cells

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