2008
DOI: 10.1016/j.jconrel.2008.06.012
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Peptide-modified vectors for nucleic acid delivery to neurons

Abstract: Neuron-targeted, nucleic acid delivery systems are important technologies for realizing the potential of gene therapy for nervous system disorders. However, neurons are difficult cells to transfect using non-viral vectors due in part to the specific and unique delivery challenges present in these cells. We have investigated several bioactive peptides for their ability to assist in overcoming delivery barriers in mammalian cells. We summarize here our recent progress in developing and applying peptidemodified p… Show more

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Cited by 30 publications
(31 citation statements)
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“…Nanoparticles have been decorated with several natural peptides borrowed either from bacteria (Mastrobattista et al 2002;Akin et al 2007) or viruses (Joanne et al 2009). These include HIVderived HGP-peptide (Kwon et al 2010), TATfusion peptide (Wadia et al 2004), influenza virus hemagglutinin HA-2 amino-terminal fusogenic peptide (Wagner et al 1992), and papillomavirus L240 peptide (Kwon et al 2008). These natural cell-penetrating peptides have also inspired several synthetic strategies, and several artificial peptides have been proposed to favor cellular delivery (Subbarao et al 1987;Wyman et al 1997;Stayton et al 2000;Jones and Sayers 2012).…”
Section: Endosome Escape Strategiesmentioning
confidence: 99%
“…Nanoparticles have been decorated with several natural peptides borrowed either from bacteria (Mastrobattista et al 2002;Akin et al 2007) or viruses (Joanne et al 2009). These include HIVderived HGP-peptide (Kwon et al 2010), TATfusion peptide (Wadia et al 2004), influenza virus hemagglutinin HA-2 amino-terminal fusogenic peptide (Wagner et al 1992), and papillomavirus L240 peptide (Kwon et al 2008). These natural cell-penetrating peptides have also inspired several synthetic strategies, and several artificial peptides have been proposed to favor cellular delivery (Subbarao et al 1987;Wyman et al 1997;Stayton et al 2000;Jones and Sayers 2012).…”
Section: Endosome Escape Strategiesmentioning
confidence: 99%
“…The efficient and statistical incorporation of peptides in copolymers by RAFT polymerization raises the possibility of efficient and well-defined synthesis of multifunctional peptide-based polymers that incorporate various monomers to facilitate delivery [15–17]. However, the properties of the base material, HPMA-oligolysine copolymer, should first be optimized before including peptides for cell targeting [18, 19] or endosomal escape [20–23].…”
Section: Introductionmentioning
confidence: 99%
“…The use of small peptides over full-length polypeptides is advantageous for nanoparticulate delivery systems because they can be easily synthesized and incorporated while having minimal effects on the physicochemical properties of the particle. The Tet1 peptide has been successfully used in our group to target polyethylenimine (PEI)-based gene delivery vehicles in vitro to cultured neuronal cells [20, 21]. …”
Section: Introductionmentioning
confidence: 99%