Peptide nanocarriers co-delivering an antisense oligonucleotide and photosensitizer elicit synergistic cytotoxicity

Tarvirdipour, Shabnam; Skowicki, Michal; Maffeis, Viviana; Abdollahi, S. Narjes; Schoenenberger, Cora-Ann; Palivan, Cornelia G.

doi:10.1016/j.jcis.2024.03.021

Journal of Colloid and Interface Science

2024

DOI: 10.1016/j.jcis.2024.03.021

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Peptide nanocarriers co-delivering an antisense oligonucleotide and photosensitizer elicit synergistic cytotoxicity

Shabnam Tarvirdipour,

Michal Skowicki,

Viviana Maffeis

et al.

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2024

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Cited by 2 publications

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Nanoassemblies designed for efficient nuclear targeting

Skowicki,

Tarvirdipour,

Kraus

et al. 2024

Advanced Drug Delivery Reviews

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Nanoassemblies designed for efficient nuclear targeting

Skowicki,

Tarvirdipour,

Kraus

et al. 2024

Advanced Drug Delivery Reviews

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Light-Promoted Lysosomal Escape of a Phthalocyanine and Antisense Oligonucleotide-Complexed G-Quadruplex for Dual Photodynamic and Antisense Therapy

Tam,

Lau,

Limanto

et al. 2024

ACS Pharmacol. Transl. Sci.

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Combination therapy has been proven as an effective strategy for cancer treatment. To this end, we report herein a selfassembled nucleic acid−based complex for dual photodynamic and antisense therapy. It contains a nucleolin-targeting As1411-based Gquadruplex platform, a partially hybridized antisense oligonucleotide 4625, which can inhibit the antiapoptotic protein B cell lymphoma-xL inducing apoptotic cell death, and a zinc(II) phthalocyanine (ZnPc)based photosensitizer held by noncovalent interactions. Through a series of in vitro experiments, we have demonstrated that this DNA complex can be internalized selectively to nucleolin-overexpressed MCF-7 and A549 cells through receptor-mediated endocytosis and is localized in the lysosomes. Upon light irradiation, the photosensitization of ZnPc triggers the formation of reactive oxygen species for cell killing and promotes the lysosomal escape of 4625 for antisense therapy. The combined therapeutic effect can eliminate the cancer cells effectively with a half maximal inhibitory concentration of ca. 0.5 μM.

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Peptide nanocarriers co-delivering an antisense oligonucleotide and photosensitizer elicit synergistic cytotoxicity

Cited by 2 publications

References 46 publications

Nanoassemblies designed for efficient nuclear targeting

Nanoassemblies designed for efficient nuclear targeting

Light-Promoted Lysosomal Escape of a Phthalocyanine and Antisense Oligonucleotide-Complexed G-Quadruplex for Dual Photodynamic and Antisense Therapy

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