Peptide nanostructures-based delivery of DNA nanomaterial therapeutics for regulating gene expression

Baral, Bineeth; Panigrahi, Bijayananda; Kar, Avishek; Tulsiyan, Kiran D.; Suryakant, Uday; Mandal, Dindyal; Subudhi, Umakanta

doi:10.1016/j.omtn.2023.07.017

Cited by 7 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Baral et al constructed W4R4 peptide bound self assembled branched DNA nanostructure (bDNA) to improve the internalization of bDNA in anionic cells. 31 Wang et al investigated the potential of cationic amino acids such as arginine and lysine in stimulating DNA assembly to produce Mg 2+ -free 2D DNA origami. When compared with Mg 2+ -assembled DNA nanostructures, DNA self-assembly depends on the neutralization of the negative charge carried by the phosphonate group of DNA and has been reported to have greater structural and serum stability.…”

Section: Design Of Dna Nanostructuresmentioning

confidence: 99%

See 1 more Smart Citation

DNA-Based Nanostructured Platforms as Drug Delivery Systems

Kumar,

Jha,

Mishra

2024

Chem Bio Eng.

View full text Add to dashboard Cite

DNA nanotechnology has recently provided a novel approach for developing safe, biocompatible, biodegradable, non-immunogenic, and non-toxic drug delivery systems. DNA nanostructures have numerous advantages for deployment as drug delivery platforms, owing to programmable assembly, ease of production, reproducibility, and precise control over size, shape, and function. DNA nanostructures can dramatically improve the delivery of poorly soluble drugs, decreasing cytotoxicity to normal tissues and improving therapeutic effectiveness. Using different conjugation methods, DNA nanostructures can be precisely integrated with a wide range of functional moieties, including proteins, peptides, aptamers, polymers, lipids, inorganic nanoparticles, and targeting groups, to enhance the nanostructure stability, extend circulation, and specify drug delivery. Smart DNA nanostructures with targeting ligands or a stimuli-responsive moiety specify therapeutic delivery to target, minimize drug loss attributable to prior drug release or off-target distribution, improve target accumulation, promote cellular internalization, bypass efflux pumps, and avoid adverse effects. Target-specific delivery by smart DNA nanostructures, in turn, maximizes drug concentration, reaching the target locations at a faster rate and preventing therapeutic failure while also lowering the dose needed for therapeutic effect. This Review provides an overview of DNA nanostructures for drug encapsulation and selective delivery to the desired sites. DNA nanostructures are a novel platform for drug delivery with improved performance that may be used to treat a variety of diseases.

show abstract

Section: Design Of Dna Nanostructuresmentioning

confidence: 99%

“…Because of the combined benefits of the DNA nanostructure and peptide activity, the hybrid structure can have a more dramatic effect in drug delivery. Baral et al constructed W4R4 peptide bound self assembled branched DNA nanostructure (bDNA) to improve the internalization of bDNA in anionic cells …”

Section: Design Of Dna Nanostructuresmentioning

confidence: 99%