1997
DOI: 10.1073/pnas.94.23.12320
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Peptide nucleic acid–DNA duplexes: Long range hole migration from an internally linked anthraquinone

Abstract: The discovery that peptide nucleic acids (PNA) mimic DNA and RNA by forming complementary duplex structures following Watson-Crick base pairing rules opens fields in biochemistry, diagnostics, and medicine for exploration. Progress requires the development of modified PNA duplexes having unique and well defined properties. We find that anthraquinone groups bound to internal positions of a PNA oligomer intercalate in the PNA-DNA hybrid. Their irradiation with near-UV light leads to electron transfer and oxidati… Show more

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Cited by 56 publications
(51 citation statements)
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“…In earlier work on this topic, it was suggested that charge transport in DNA occurs by ''hopping'' of a radical cation localized on one base to a neighboring base (30,31). This mechanism does not require extensive coupling through a -way of bridge orbitals, and thus the characterization of the distance dependence with ␤ is misleading.…”
mentioning
confidence: 99%
“…In earlier work on this topic, it was suggested that charge transport in DNA occurs by ''hopping'' of a radical cation localized on one base to a neighboring base (30,31). This mechanism does not require extensive coupling through a -way of bridge orbitals, and thus the characterization of the distance dependence with ␤ is misleading.…”
mentioning
confidence: 99%
“…It appears that the only additional requirement for recognition by the enzyme is phosphate groups on the dimer-containing strand (3,4). For these reasons, we suspected that photolyase might retain its ability to recognize and repair thymine dimers contained on the DNA strand of a DNA͞PNA hybrid duplex (5)(6)(7)(8). We carried out a series of experiments to assess this possibility.…”
mentioning
confidence: 99%
“…However, one study has demonstrated that an injected charge into a PNA can move via a hopping mechanism to a guanine duplet on the complementary DNA strand. 70 As discussed previously, excited TiO 2 nanoconjugates are also capable of generation of reactive oxygen species that possess short half life and may travel short distances. [49][50][51] Also, it has been mentioned how coating TiO 2 nanoparticles with chemicals such as GIE reduces interaction between the nanoparticle and DNA backbone and may shield the nanoparticle from the aqueous environment, thus inhibiting the production of reactive oxygen species.…”
Section: Nucleic Acid-tio 2 Bionanoconjugatesmentioning
confidence: 99%