Peptide nucleic acids: structure, properties, applications, strategies and practice of chemical synthesis

Abstract

The information on the structure and properties of The information on the structure and properties of peptide nucleic acids (PNA) is generalised. The use of PNA peptide nucleic acids (PNA) is generalised. The use of PNA oligomers in biomolecular studies and biotechnology is exempli-oligomers in biomolecular studies and biotechnology is exemplified. The published data on the most important methods for the fied. The published data on the most important methods for the chemical synthesis of PNA oligomers with the main emphasis on chemical synthesis of PNA oligomers with the main emphasis on the efficiency of condensation reactions are considered. The the efficiency of condensation reactions are considered. The methods for PNA synthesis are systematised; their advantages methods for PNA synthesis are systematised; their advantages and disadvantages are discussed. Some recommendations for and disadvantages are discussed. Some recommendations for optimisation of the condensation procedure and synthesis of optimisation of the condensation procedure and synthesis of PNA are presented. The bibliography includes 153 references PNA are presented. The bibliography includes 153 references. .

A PNA‐DNA2 Triple‐Helix Molecular Switch‐Based Colorimetric Sensor for Sensitive and Specific Detection of microRNAs from Cancer Cells

“…The homopurine PNA oligonucleotide was manually prepared by the method of solidphase peptide synthesis and characterized according to our previously published literature. [49,50] All the PNA oligomer was purified by high-quality pre-packed column (Agilent Eclipse XDB-C18) and characterized by mass analysis. Their purities were greater than 99 % according to HPLC (Agilent).…”

Combination of the Opposing Effects of Silver Nanoparticles and Peptide Nucleic Acids on Dye-Sensitized Solar Cells to Enhance their Respective Positive Influence

“…Peptide nucleic acids (PNA) are synthetic molecules with a peptide backbone that mimic DNA (41)(42)(43). As a peptide, PNA can easily be modified with amino acids containing different functional groups.…”

Molecular Beacons of Xeno-Nucleic Acid for Detecting Nucleic Acid

“…Through efforts, Peter Nielsen and Ole Buchardt discovered peptide nucleic acid (PNA), a nucleobase oligomer, in the 1990s 35. The structure of PNA is similar to oligonucleotides-based MBs, whose backbone is made from repeating N-(2-aminoethyl) glycine units linked by peptide bonds instead of a negatively charged sugar-phosphate backbone 36,37. Different bases (purines and pyrimidines) are joined to the backbone with methylene carbonyl linkages (Figure 3 ) 38.…”