2022
DOI: 10.1039/d1cb00246e
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Peptide/protein-based macrocycles: from biological synthesis to biomedical applications

Abstract: Peptide- and protein-based macrocycles have been biologically synthesized and evolved with enhanced stability and high bioactivity that are superior to their linear counterparts for diverse biomedical applications.

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Cited by 7 publications
(3 citation statements)
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“…[61] Cyclization of proteins by covalently linking the N-and Ctermini of the protein backbone leads to increased rigidity and a higher entropy barrier for protein unfolding. [62] Various approaches have been explored for protein cyclization, such as chemical synthesis, [63] sortase-mediated cyclization, [14] and split inteins. [64,65] A protein cyclization strategy based on the SpyCatcher/Tag system, called SpyRing, [54] was reported to significantly improve the thermal resilience of various enzymes, such as βlactamase, [66] phytase, [67] luciferase [68] and xylanase.…”
Section: Cyclization Of Enzymes For Thermal Resiliencementioning
confidence: 99%
See 1 more Smart Citation
“…[61] Cyclization of proteins by covalently linking the N-and Ctermini of the protein backbone leads to increased rigidity and a higher entropy barrier for protein unfolding. [62] Various approaches have been explored for protein cyclization, such as chemical synthesis, [63] sortase-mediated cyclization, [14] and split inteins. [64,65] A protein cyclization strategy based on the SpyCatcher/Tag system, called SpyRing, [54] was reported to significantly improve the thermal resilience of various enzymes, such as βlactamase, [66] phytase, [67] luciferase [68] and xylanase.…”
Section: Cyclization Of Enzymes For Thermal Resiliencementioning
confidence: 99%
“…Protein cyclization technology has been developed as a powerful method to enhance the thermal resilience of enzymes [61] . Cyclization of proteins by covalently linking the N‐ and C‐termini of the protein backbone leads to increased rigidity and a higher entropy barrier for protein unfolding [62] . Various approaches have been explored for protein cyclization, such as chemical synthesis, [63] sortase‐mediated cyclization, [14] and split inteins [64,65] …”
Section: Applications Of the Catcher/tag Systems – Expanding The Rang...mentioning
confidence: 99%
“…Within this realm, N -methylated macrocyclic peptides ( N -MeMPs) have emerged as a class of cyclic compounds exhibiting promising medicinal properties. Since their molecular weights (MW) are 600 Da or higher, their chemical actions are not confined by Lipinski’s rule of 5, which describes traditional therapeutics with a molecular mass of less than 500 Da, no more than 5 hydrogen bond donors, no more than 10 hydrogen bond acceptors, and an octanol–water partition coefficient not greater than 5. Their biochemical and therapeutic attributes are expected to fill the gap in chemical space between small molecules and linear peptides. …”
Section: Introductionmentioning
confidence: 99%