Peptide receptor therapy with 111IN-DTPA-octreotide (OC)

Krenning, Eric P.; Valkema, Roelf; Kooij, P. P. M.; Breeman, W. A. P.; Wh, Bakker; deHerder, W.W.; Vaneijck, C. H. J.; DeJong, M; Pauwels, Stanislas

doi:10.1016/s0959-8049(97)86140-0

Cited by 3 publications

(2 citation statements)

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“…The aqueous coordination chemistry of Ln III complexes has been actively studied over the last 20 years, driven largely by the medical applications of these ions. Complexes containing β-emitting isotopes of lutetium, samarium, promethium, or holmium have been used to target and destroy cancers. − Texaphyrin complexes have shown potential in photodynamic therapy (Lu) for vascular disease , and cancer and also as radiosensitizers (Gd) for cancer. , The unique optical properties of lanthanides, notably terbium and europium, have resulted in many biophysical applications such as time-resolved fluorescence assays. , A lanthanum carbonate formulation has recently been approved for treating hyperphosphataemia in patients with kidney failure. , Gadolinium complexes are widely used in radiology as contrast agents for magnetic resonance imaging (MRI) scans. , …”

Section: Introductionmentioning

confidence: 99%

Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide

et al. 2007

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The GdIII-based magnetic resonance imaging contrast agent MS-325 targets the blood protein serum albumin, resulting in an increased efficacy (relaxivity) as a relaxation agent. MS-325 showed different relaxivities when bound to serum albumin from different species, e.g., r1=30.5 mM-1 s-1 (rabbit) vs 46.3 mM-1 s-1 (human) at 35 degrees C and 0.47 T. To investigate the mechanism for this difference, surrogate complexes were prepared where the GdIII ion was replaced by other LnIII ions. Fluorescence lifetime measurements of the EuIII analogue indicated that the hydration number was q=1 and did not change when bound to either human, rat, rabbit, pig, or dog serum albumin. The YbIII analogue, YbL1, was prepared and characterized by 1H NMR. Line-shape analysis of the paramagnetic-shifted 1H NMR resonances in the presence of increasing amounts of human (HSA) or rabbit (RSA) serum albumin allowed estimation of the transverse relaxation rate, R2, of these resonances for the protein-bound YbL1. The rotational correlation time of YbL1 was calculated from R2, and the Yb-H distance and was tauR=8+/-1 ns when bound to HSA and 13+/-2 ns when bound to RSA. The water exchange rate at the DyIII analogue, DyL1, was determined from variable-temperature R2 measurements at 9.4 T when DyL1 was bound to either HSA or RSA. At 37 degrees C, water exchange at DyL1 was (31+/-5)x10(6) s-1 when bound to HSA but (3.8+/-0.2)x10(6) s-1 when bound to RSA. Slower water exchange upon RSA binding explains the differences in relaxivity observed. The approach of using surrogate lanthanides to identify specific molecular parameters influencing relaxivity is applicable to other protein-targeted GdIII contrast agents.

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Section: Introductionmentioning

confidence: 99%

Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide

et al. 2007

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“…Moreover, the confidence interval of this relative bias included the value 0 in our comparison [bias = 3.70 ± 8.29% (CI: −1.09; 8.49)] that is of major importance in a context of optimizing the characterization of NETs in Comparison of AUC IDIF with AUC PBIF3-7 using IDIF Bland-Altman plot. We also studied physiological Ki-metrics because spleen and liver uptakes were historically used in scintigraphy to estimate SSTr density expression in NETs (33). Using PBIF 3-7 , we found relatively same results for Ki-spleen than for Ki-tumor estimation with a low relative bias [Ki ratio = 1.05 ± 0.08, R 2 = 0.96 (slope = 1.05), bias = 4.66 ± 7.59% (CI: 0.26; 9.03)].…”

Section: Discussionmentioning

confidence: 99%

Population-based input function (PBIF) applied to dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition

et al. 2022

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RationalTo validate a population-based input function (PBIF) model that alleviates the need for scanning since injection time in dynamic whole-body (WBdyn) PET.MethodsThirty-seven patients with suspected/known well-differentiated neuroendocrine tumors were included (GAPETNET trial NTC03576040). All WBdyn 68Ga-DOTATOC-PET/CT acquisitions were performed on a digital PET system (one heart-centered 6 min-step followed by nine WB-passes). The PBIF model was built from 20 image-derived input functions (IDIFs) obtained from a respective number of patients’ WBdyn exams using an automated left-ventricle segmentation tool. All IDIF peaks were aligned to the median time-to-peak, normalized to patient weight and administrated activity, and then fitted to an exponential model function. PBIF was then applied to 17 independent patient studies by scaling it to match the respective IDIF section at 20–55 min post-injection time windows corresponding to WB-passes 3–7. The ratio of area under the curves (AUCs) of IDIFs and PBIF3–7 were compared using a Bland–Altman analysis (mean bias ± SD). The Patlak-estimated mean Ki for physiological uptake (Ki-liver and Ki-spleen) and tumor lesions (Ki-tumor) using either IDIF or PBIF were also compared.ResultsThe mean AUC ratio (PBIF/IDIF) was 0.98 ± 0.06. The mean Ki bias between PBIF3–7 and IDIF was −2.6 ± 6.2% (confidence interval, CI: −5.8; 0.6). For Ki-spleen and Ki-tumor, low relative bias with low SD were found [4.65 ± 7.59% (CI: 0.26; 9.03) and 3.70 ± 8.29% (CI: −1.09; 8.49) respectively]. For Ki-liver analysis, relative bias and SD were slightly higher [7.43 ± 13.13% (CI: −0.15; 15.01)].ConclusionOur study showed that the PBIF approach allows for reduction in WBdyn DOTATOC-PET/CT acquisition times with a minimum gain of 20 min.

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Somatostatin receptor scintigraphy in the follow-up of patients with differentiated thyroid cancer

Haslinghuis

Krenning

Herder

et al. 2001

J Endocrinol Invest

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Peptide receptor therapy with 111IN-DTPA-octreotide (OC)

Cited by 3 publications

References 0 publications

Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide

Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide

Population-based input function (PBIF) applied to dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition

Somatostatin receptor scintigraphy in the follow-up of patients with differentiated thyroid cancer

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