2020
DOI: 10.1101/2020.05.26.100743
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Peptide recognition and dephosphorylation by the vaccinia VH1 phosphatase

Abstract: The VH1 protein encoded by the highly conserved H1 locus of orthopoxviruses is a dualspecificity phosphatase (DUSPs) that hydrolyzes phosphate groups from phosphorylated tyrosine, serine, and threonine residues of viral and host cell proteins. Because the DUSP activities are required for virus replication, VH1 is a prime target for the development of therapeutic inhibitors. However, the presentation of a shallow catalytic site has thwarted all drug development efforts. As an alternative to direct targeting of … Show more

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