Peptide synthesis by means of polymer-anchored N-hydroxy compound. 1. Preparation of simple peptides

Amination of Poly(vinylbenzyl chloride) with N,N-Dimethylformamide

“…[2][3][4][5][6] This property can be important when reactions are conducted between nucleophilic reagents and polyVBC: the DMF compatibilizes the two and allows the reaction to occur within the polymer network. [7][8][9] The success of these reactions is predicated on the inertness of DMF as a reagent.…”

“…Its usefulness stems from the propensity of the pendant −CH 2 Cl groups to undergo reaction with nucleophiles. In numerous organic syntheses, N , N -dimethylformamide (DMF) is used as the solvent because of its ability to dissolve compounds with a range of polarity differences. − This property can be important when reactions are conducted between nucleophilic reagents and polyVBC: the DMF compatibilizes the two and allows the reaction to occur within the polymer network. − The success of these reactions is predicated on the inertness of DMF as a reagent.…”

A Versatile New Synthetic Route to 1N-Hydroxyindazoles

“…Despite the paucity of useful synthetic methods, 1 N -hydroxyindazole derivatives have nonetheless been claimed in patent applications as kinase inhibitors, peptide-coupling reagents, optoelectronic materials, and dye additives . Recently related N -hydroxypyrazole-containing compounds were found to display potent antitumor activity in rodent models …”