Peptide‐Templated Synthesis of TiO₂ Nanofibers with Tunable Photocatalytic Activity

Abstract

Nanofabrication based on biological templates has attracted considerable interest because of its applicationsi n materials science and biomedicine. Herein, af acile method is reported for the synthesis of well-definedT iO 2 nanofibers by using as imple N-(9-fluorenylmethoxycarbonyl)-protected phenylalanine-phenylalanine-aspartic acid tripeptide (Fmoc-Phe-Phe-Asp-OH, Fmoc-FFD) as the template. Compared with other synthetic methods of inorganicn anomaterials, these self-assembling peptides could control the structure and the catalytic activityo ft he synthesized nanomaterials produced under mild synthetic conditions. The as-synthesized peptide-TiO 2 hybrid nanofibers and the calcined TiO 2 nanofibersw ere characterizedb yu sing transmission electron microscopy (TEM), scanning electron microscopy (SEM), circular dichroism (CD) spectroscopy,a nd X-ray diffraction (XRD).T he resultss how that well-defined TiO 2 nanofibers could form when the pH of the peptide solution was 5-7, whereas nanoparticles formed when the pH was 8. Moreover,t he peptide-templated TiO 2 nanofibers showedi mprovedp hotocatalytic activity for the degradation of methyl orange (MO). Finally,t he photocatalytic activity of the TiO 2 could be controlled by adjusting the pH of the peptides olution during the syntheticp rocess.

Selective Photocatalytic Activities of Amino Acids/Peptide-Ti3C2Tx-TiO2 Composites Induced by Calcination: Adsorption Enhancement vs Charge Transfer Enhancement

“…Previous studies have reported that the peptide-modified TiO 2 can selectively and rapidly degrade streptavidin but is greatly inhibited for the photocatalytic degradation of lysozyme . The N -(9-fluorenylmethoxycarbonyl)-protected phenylalanine-phenyl-alanine-aspartic acid tripeptide can control the structure and photocatalytic activity of as-synthesized peptide-TiO 2 hybrid nanofibers via the calcination process . In summary, the P-T-T composite has selective photocatalytic degradation properties toward different organic contaminants induced by calcination.…”

“…44 The N-(9-fluorenylmethoxycarbonyl)-protected phenylalanine-phenyl-alanine-aspartic acid tripeptide can control the structure and photocatalytic activity of as-synthesized peptide-TiO 2 hybrid nanofibers via the calcination process. 45 In summary, the P-T-T composite has selective photocatalytic degradation properties toward different organic contaminants induced by calcination. In addition, after five successive measurements in Figure S3g− i, the E D and E A values toward TC-HCl for all of the composites decrease with the increase of the number of cycles.…”

Systems chemistry of peptide-assemblies for biochemical transformations

“…The design of active sites based on artificial systems via using the concept of supramolecular assembly is the key to gain further insight into the natural evolution of enzymes. [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71] 2.1 Peptide based self-assembly as esterase Esterase and in particular carbonic anhydrases (CAs) are among the ubiquitous metalloenzymes that regulate various physiological functions along with implications in the field of biotechnology. [72][73][74] Despite numerous efforts for artificially fabricating CA mimics, the complex folding patterns and the stability of the peptide building blocks pose tremendous hurdles.…”

“…The design of active sites based on artificial systems via using the concept of supramolecular assembly is the key to gain further insight into the natural evolution of enzymes. 53–71…”

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

“…[ 13–15 ] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [ 16–22 ] and important biofunctions, such as drug delivery, [ 23–25 ] tissue engineering, [ 26–28 ] regenerative medicine, [ 29–31 ] and biomineralization. [ 32–35 ] Moreover, many studies have disclosed that self‐assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself.…”