Peptidergic innervation of human esophageal and cardiac carcinoma

Lu, Shuaiyao; Zhou, Yan; Que, Haiping; Liu, Shaojun

doi:10.3748/wjg.v9.i3.399

Cited by 37 publications

(15 citation statements)

References 30 publications

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“…Tumours induce innervation around themselves 3 10 and, in general, high levels of innervation in tumours correlate with a poor disease outcome 2 7 . Tumour cells have the ability to produce substances, such as Nerve Growth Factor (NGF), that stimulate the growth and improve the survival of nerve cells 11 12 .…”

Section: Biological Backgroundmentioning

confidence: 99%

“…Traditionally, the nervous system has not been considered to be actively involved in the process of metastasis. However, recent studies have demonstrated the presence of neurons in peritumoural regions of several human tumours, and the number of tumour-associated neurons has been correlated with metastases 2 3 . The relative importance of pre-existing versus newly-formed neurons to metastasis is not understood.…”

mentioning

confidence: 99%

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Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach

Lolas¹,

Bianchi²,

Syrigos³

2016

Sci Rep

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It is well-known that tumours induce the formation of a lymphatic and a blood vasculature around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as neoneurogenesis. The relationship between tumour progression and the nervous system is still poorly understood and is likely to involve a multitude of factors. It is therefore relevant to study tumour-nerve interactions through mathematical modelling: this may reveal the most significant factors of the plethora of interacting elements regulating neoneurogenesis. The present work is a first attempt to model the neurobiological aspect of cancer development through a system of differential equations. The model confirms the experimental observations that a tumour is able to promote nerve formation/elongation around itself, and that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of a tumour. Our results also reflect the observation that high stress levels (represented by higher norepinephrine release by sympathetic nerves) contribute to tumour development and spread, indicating a mutually beneficial relationship between tumour cells and neurons. The model predictions suggest novel therapeutic strategies, aimed at blocking the stress effects on tumour growth and dissemination.

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Section: Biological Backgroundmentioning

confidence: 99%

mentioning

confidence: 99%

Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach

Lolas¹,

Bianchi²,

Syrigos³

2016

Sci Rep

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“…In addition to the above discussed induction of metastasis formation, the innervation of tumors might support a proinflammatory milieu by the release of the according neurotransmitters. For example, peptidergic nerve fibres have been found in esophageal and cardiac carcinoma [ 43 ]. In that study, substantial amounts of substance P have been found, which is a key mediator of inflammatory processes [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment

et al. 2010

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BackgroundTumor cells interact with the cells of the microenvironment not only by cell-cell-contacts but also by the release of signal substances. These substances are known to induce tumor vascularization, especially under hypoxic conditions, but are also supposed to provoke other processes such as tumor innervation and inflammatory conditions. Inflammation is mediated by two organ systems, the neuroendocrine system and the immune system. Therefore, we investigated the influence of substances released by PC-3 human prostate carcinoma cells on SH-SY5Y neuroblastoma cells as well as neutrophil granulocytes and cytotoxic T lymphocytes, especially with regard to their migratory activity.ResultsPC-3 cells express several cytokines and growth factors including vascular endothelial growth factors, fibroblast growth factors, interleukins and neurotrophic factors. SH-SY5Y cells are impaired in their migratory activity by PC-3 cell culture supernatant, but orientate chemotactically towards the source. Neutrophil granulocytes increase their locomotory activity only in response to cell culture supernantant of hypoxic but not of normoxic PC-3 cells. In contrast, cytotoxic T lymphocytes do not change their migratory activity in response to either culture supernatant, but increase their cytotoxicity, whereas supernatant of normoxic PC-3 cells leads to a stronger increase than that of hypoxic PC-3 cells.ConclusionsPC-3 cells release several signal substances that influence the behavior of the cells in the tumor's microenvironment, whereas no clear pattern towards proinflammatory or immunosuppressive conditions can be seen.

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“…Based on the in vitro data, it is, therefore, reasonable to expect an enhanced density of nerve fibers within the tumor. However, while some studies do provide evidence of neurogenesis within the tumor [34, 66, 68, 72–74], others report normal or even reduced neuronal density within the tumor foci, and the presence of nerve fibers exclusively around the vasculature or in the peripheral stroma of the tumor [75–78]. The challenge in quantifying neuronal fibers by immunohistochemistry and the difficulty of differentiating between autonomic and sensory fibers in tissue may contribute to the discrepancy of reported tumor innervation.…”

Section: Afferent Nervous Systemmentioning

confidence: 99%

Schwann cells: a new player in the tumor microenvironment

Bunimovich

Keskinov

Shurin

2016

Cancer Immunol Immunother

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Cancerous cells must cooperate with the surrounding stroma and non-malignant cells within the microenvironment to support the growth and invasion of the tumor. The nervous system is a component of every organ system of the body, and therefore, is invariably at the front line of the tumor invasion. Due to the complexity of the nervous system physiology, this review separately discusses the contributions of the central and peripheral nervous systems to the tumorigenesis and tumor progression. We further focus the discussion on the evidence that Schwann cells aid in tumor growth and invasion. Schwann cells, a largely unexplored element of the tumor microenvironment, may participate in the creation of tumor-favorable conditions through both bi-directional interaction with cancer cells and the facilitation of the immune-suppressive microenvironment through the mechanism of neural repair and immunomodulation.

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Peptidergic innervation of human esophageal and cardiac carcinoma

Cited by 37 publications

References 30 publications

Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach

Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach

PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment

Schwann cells: a new player in the tumor microenvironment

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