Peptidergic intraepidermal nerve fibers in the skin contribute to the neuropathic pain in paclitaxel-induced peripheral neuropathy

Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy

“…Effects of Paclitaxel on Mechanical Sensitivity and ICSS. The effects of paclitaxel on mechanical sensitivity thresholds reported here agree with previous studies in rodents that examined the time course and extent of mechanical hypersensitivity after paclitaxel treatment (Polomano et al, 2001;Pascual et al, 2010;Boyette-Davis et al, 2011;Hwang et al, 2012;Ko et al, 2014;Toma et al, 2017;Legakis et al, 2018). In addition, although females were found to be more sensitive than males to paclitaxelinduced cold allodynia, the present results agree with previous findings that there were no sex differences in the development of paclitaxel-induced mechanical hypersensitivity (Hwang et al, 2012;Naji-Esfahani et al, 2016;Legakis et al, 2018).…”

“…Accordingly, the present study examined the effects of repeated morphine administration on ICSS in rats treated with paclitaxel or its vehicle. The effects of repeated morphine on ICSS were compared with the effects of the same regimen of repeated morphine treatment on paclitaxelinduced mechanical allodynia (Polomano et al, 2001;Pascual et al, 2010;Boyette-Davis et al, 2011;Hwang et al, 2012;Ko et al, 2014). Studies were conducted in male and female rats because sex differences have been reported previously for some paclitaxel effects (Naji-Esfahani et al, 2016) and for the rewarding and antinociceptive effects of morphine (Cicero et al, 2003;Lynch, 2006;Craft, 2008;Lynch et al, 2013).…”

Comparison of Chemotherapy Effects on Mechanical Sensitivity and Food-Maintained Operant Responding in Male and Female Rats

“…induced mechanical hypersensitivity in the present study generally agrees with previous studies in rats and mice using paclitaxel (Polomano et al, 2001;Pascual et al, 2010;Boyette-Davis et al, 2011;Hwang et al, 2012;Ko et al, 2014;Toma et al, 2017;, vincristine (Ji et al, 2013;Linglu et al, 2014;Amoateng et al, 2015), oxaliplatin Liu et al, 2013;Fujita et al, 2015), and bortezomib (Chiorazzi et al, 2013;Janes et al, 2013;Yamamoto et al, 2015). However, direct comparison of chemotherapy effects has been complicated by use of different doses and dosing regimens across studies.…”

Neuropathic Pain and Nerve Growth Factor in Chemotherapy-Induced Peripheral Neuropathy: Prospective Clinical-Pathological Study

“…1 Furthermore, differences on criteria for defining CIPN severity, the statistical approach, and methodological differences in the determination of NGF could be also underlying the differences obtained with our results. On the other hand, a reduction of IENFD has been consistently reported in almost all rodent models of CIPN tested, including treatments with cisplatin, 26 paclitaxel, 27,28 and BTZ, 29 especially restricted to the sensory axons terminal arbor without degeneration of the subepidermal nerve bundles. 30 However, contradictory results emerge from clinical studies, including our work, that do not allow establishing uniform conclusions regarding the involvement of small fibers by each drug (Table 3).…”