Peptidergic transmission in the brain. III. Hippocampal inhibition by the amygdala

Smock, Tim; Albeck, David; McMechen, P.

doi:10.1016/0196-9781(91)90165-l

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…The latenty of these AVT effects ranged from sec onds to a small number of minutes, as reported earlier for vasopressin [17,18,[21][22][23][24][25], This rapid action is con sistent with signal transduction mechanisms involving G-protein-coupled receptor mechanisms.…”

Section: Discussionmentioning

confidence: 70%

“…The enhancement of sensory responses and sponta neous discharge produced by AVT resembles the mainly excitatory effect of vasopressin that has been seen in numerous neuronal systems in mammals [17,18,21,22], Suppressive neuronal effects of AVT were clearly evident, but neurons showing such effects were sampled among those showing response enhancement and pervasive sup pressive neural effects like those described for the vasopressinergic system in the hippocampus [23][24][25] were not seen. The latenty of these AVT effects ranged from sec onds to a small number of minutes, as reported earlier for vasopressin [17,18,[21][22][23][24][25], This rapid action is con sistent with signal transduction mechanisms involving G-protein-coupled receptor mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Neurophysiological Effects of Vasotocin and Corticosterone on Medullary Neurons: Implications for Hormonal Control of Amphibian Courtship Behavior

Rose

Kinnaird²,

Moore³

1995

Neuroendocrinology

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Research on a wide variety of vertebrates, from fish to mammals, reveals that corticosteroid hormones and vasotocin-like neuropeptides can potently modulate reproductive behaviors. But, it is not clear how the behavioral effects of these chemical messengers relate to functional properties of behavior-controlling neurons. This problem was investigated in the roughskin newt, Taricha granulosa, an amphibian in which the administration of arginine vasotocin (AVT) facilitates and corticosterone (CORT) inhibits courtship clasping of females by males. In waking, immobilized male newts, neurophysiological effects of AVT and CORT were studied in neurons in the rostral medulla due to the probable role of these neurons in the control of clasping. Topical medullary application of a clasp-facilitating dose of AVT produced a rapid increase in neuronal responsiveness to pressure on the cloaca, a trigger stimulus for clasping responses. Neuronal responses to noncloacal somatic stimuli and to moving visual stimuli were also enhanced. Systemic CORT administration, which has previously been shown to depress newt medullary neuronal sensory responsiveness, reversed the action of AVT such that the peptide depressed sensory responsiveness when applied 30 min after CORT. When AVT application prededed CORT injection by 10–17 min, however, the usual suppressive CORT effect was reversed and this treatment resulted in a rapidly appearing potentiation of neuronal activity and enhanced somatic sensory responsiveness. If the interval between AVT and CORT was increased to 30 min, the steroid caused a rapid depression of firing and a diminished somatic sensory responsiveness in most neurons, similar to what occurs in newts treated with CORT alone. These results indicate that neurophysiological actions of AVT or CORT depend on the type of prior hormonal exposure (pretreatment with AVT of CORT) and the time interval between hormone actions.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Neurophysiological Effects of Vasotocin and Corticosterone on Medullary Neurons: Implications for Hormonal Control of Amphibian Courtship Behavior

Rose

Kinnaird²,

Moore³

1995

Neuroendocrinology

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“…The change in the number of the above-described groups of neurons against the background of the subsequent application of lysinevasopressin is evidently associated with its diverse effect on cell metabolism and the processes of protein synthesis [8,13].…”

Section: Discussion Of Resultsmentioning

confidence: 99%

The processes of anticipation and evaluation of the results of behavior and their cellular neurochemical mechanisms

Andrianov¹

1994

Neurosci Behav Physiol

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The cellular neurochemical mechanisms of the goal-directed activity of cats under free behavior conditions were studied using the method of the microiontophoretic application of biologically active substances to individual neurons of the visual area of the cerebral cortex. Two experimental situations were used in the study. The first consisted of the alternation of the animal's instrumental reactions in the form of pedal-pressing with following reinforcement and of unexpected deliveries of milk in the food dispenser, and the second consisted of the alternation of the instrumental reactions with following reinforcement and of such reactions without reinforcement. An association was demonstrated of the cellular neurochemical mechanisms with the processes of the anticipation, perception, and evaluation of the results of the goal-directed activity.

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The output of the hippocampus is inhibited during social behavior in the male rat

et al. 1996

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During sexual behavior in the male rat, peptidergic cells in the medial amygdaloid nucleus become active and release a vasopressin-like peptide. The present experiments were designed to examine hippocampal changes as a result of this peptide's action during sexual behaviors. Chronic field-potential recordings from the hippocampus of male rats were acquired in a wide variety of social and nonsocial circumstances. Hippocampal responses that resemble the known action of the vasopressin-like peptide were seen only with social stimuli such as sexual stimuli and stimuli that led to aggressive behavior between males. The results show that the occasions of peptide action in the hippocampus correlate with the occasions of peptide release as determined by recording from the peptidergic cell bodies. The results are interpreted to indicate that the amygdala projection to the hippocampus has a special role to play in social behavior.

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Peptidergic transmission in the brain. III. Hippocampal inhibition by the amygdala

Cited by 10 publications

References 14 publications

Neurophysiological Effects of Vasotocin and Corticosterone on Medullary Neurons: Implications for Hormonal Control of Amphibian Courtship Behavior

Neurophysiological Effects of Vasotocin and Corticosterone on Medullary Neurons: Implications for Hormonal Control of Amphibian Courtship Behavior

The processes of anticipation and evaluation of the results of behavior and their cellular neurochemical mechanisms

The output of the hippocampus is inhibited during social behavior in the male rat

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