Peptides-carrageenan-xanthan gum: Printing mechanism and anti-oxidation under in vitro digestion

Zhan, Junqi; Yu, Wentao; Fu, Jingjing; Li, Gao-shang; Hu, Yaqin; Chen, Yuewen

doi:10.1016/j.fbio.2023.102546

Food Bioscience

2023

DOI: 10.1016/j.fbio.2023.102546

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Peptides-carrageenan-xanthan gum: Printing mechanism and anti-oxidation under in vitro digestion

Junqi Zhan

Wentao Yu

Jingjing Fu

et al.

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Cited by 7 publications

References 32 publications

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Antioxidant synergistic anti‐inflammatory effect in the MAPK/NF‐κB pathway of peptide KGEYNK (KK‐6) from giant salamander (Andrias davidianus)

Zhan,

Wu,

et al. 2024

J Sci Food Agric

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BACKGROUNDGiant salamander protein peptide is a peptide with rich functional properties. Giant salamander protein peptide KGEYNK (KK‐6) is a peptide with both antioxidant and anti‐inflammatory properties. The antioxidant and anti‐inflammatory mechanisms of KK‐6 are still unclear. When we studied the functional mechanism of KK‐6, we found that the antioxidant property of KK‐6 has a synergistic and promoting effect on anti‐inflammatory properties.RESULTSKK‐6 enhances cellular resistance to LPS via the MAPK/NF‐κB signaling pathway, leading to increased levels of inflammatory factors: interleukin‐1β (764.81 ng mL−1), interleukin‐6 (1.06 ng mL−1) and tumor necrosis factor‐α (4440.45 ng mL−1). KK‐6 demonstrates potent antioxidant properties by activating the Nrf2 signaling pathway, resulting in elevated levels of antioxidant enzymes (glutathione peroxidase: 0.03 μg mL−1; superoxide dismutase: 0.589 μg mL−1) and a reduction in the concentration of the oxidative product malondialdehyde (967.05 μg mL−1).CONCLUSIONOur findings highlight the great potential of KK‐6, a peptide extracted from giant salamander protein, as a remedy for intestinal inflammation. Through its dual role as an antioxidant and anti‐inflammatory agent, KK‐6 offers a promising avenue for alleviating inflammation‐related damage and oxidative stress. This study lays the foundation for further exploration of giant salamander products and highlights their importance in health and novel food development. © 2024 Society of Chemical Industry.

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Antioxidant synergistic anti‐inflammatory effect in the MAPK/NF‐κB pathway of peptide KGEYNK (KK‐6) from giant salamander (Andrias davidianus)

Zhan,

Wu,

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

show abstract

Exploring the Superiorities of Restructured Peaches During Freeze-Drying and Storage

Xie,

Bi,

Jin

2025

Food Bioprocess Technol

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Review on emerging trends and challenges in the modification of xanthan gum for various applications

Kumar,

Gihar

et al. 2024

Carbohydrate Research

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Peptides-carrageenan-xanthan gum: Printing mechanism and anti-oxidation under in vitro digestion

Cited by 7 publications

References 32 publications

Antioxidant synergistic anti‐inflammatory effect in the MAPK/NF‐κB pathway of peptide KGEYNK (KK‐6) from giant salamander (Andrias davidianus)

Antioxidant synergistic anti‐inflammatory effect in the MAPK/NF‐κB pathway of peptide KGEYNK (KK‐6) from giant salamander (Andrias davidianus)

Exploring the Superiorities of Restructured Peaches During Freeze-Drying and Storage

Review on emerging trends and challenges in the modification of xanthan gum for various applications

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