Peptides for trans‐blood–brain barrier delivery

Blades, Reuben; Ittner, Lars M.; Tietz, Ole

doi:10.1002/jlcr.4023

Cited by 7 publications

(2 citation statements)

References 153 publications

(285 reference statements)

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“…The moderate BBB penetration capability of MB-CPDs demonstrated their potential for in vivo therapeutic applications. A further increase of the BBB penetration capability of MB-CPDs could be achieved by coupling a cell-penetrating peptide. , …”

Section: Resultsmentioning

confidence: 99%

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Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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The abnormal aggregation of β-amyloid protein (Aβ) is one of the main pathological hallmarks of Alzheimer's disease (AD), and thus development of potent scavengers targeting Aβ is considered an effective strategy for AD treatment. Herein, photosensitizer-doped carbonized polymer dots (PS-CPDs) were synthesized by a one-step hydrothermal method using photosensitizer (PS) and o-phenylenediamine (oPD) as precursors, and furtherly applied to inhibit Aβ aggregation via photooxygenation. The inhibition efficiency of such PS-CPDs can be adjusted by varying the type of photosensitizer, and among them, methylene blue-doped carbonized polymer dots (MB-CPDs) showed the strongest photooxygenation inhibition capability. The results demonstrated that under 650 nm NIR light irradiation, MB-CPDs (2 μg/mL) produced reactive oxygen species (ROS) to efficiently inhibit Aβ fibrillization and disaggregate mature Aβ fibrils and increased the cultured cell viability from 50% to 83%. In vivo studies confirmed that MB-CPDs extended the lifespan of AD nematodes by 4 days. Notably, the inhibitory capability of MB-CPDs is much stronger than that of MB and previously reported carbonized polymer dots. This work indicated that potent photooxygenation carbon dots can be obtained by using a photosensitizer as one of the precursors, and the results have provided new insights into the design of potent photooxygenation carbon nanomaterials targeting Aβ in AD treatment.

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Section: Resultsmentioning

confidence: 99%

“…A further increase of the BBB penetration capability of MB-CPDs could be achieved by coupling a cell-penetrating peptide. 66,67…”

Section: Resultsmentioning

confidence: 99%

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Lin,

Zhang,

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Potential of miRNA as Imaging Targets for PET

Zientek,

Thompson,

Aigbirhio

et al. 2024

Helvetica Chimica Acta

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Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET imaging agent candidates are considered. One such possible target is microRNA (miRNA) and herein, we discuss the potential of miRNA for PET imaging. With the aim of addressing key strategies for imaging miRNA with PET, we identify three distinct approaches as follows: small molecules directly targeting miRNA, small molecules indirectly targeting Argonaute 2 (AGO2)‐protein complexes, and direct chemical modification of antisense oligonucleotides. The radiosynthetic approaches are based on the methods of direct radiolabelling of respective antisense oligonucleotides and several examples are described herein, showcasing the potential of miRNA in PET imaging. Whilst these approaches offer different radiolabelling strategies, application of these radiolabelled molecules towards PET imaging of miRNA are scarce with only one, limited example applied to bone remodeling reported in the literature.

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Therapeutic Potential of CPPs

Langel

2023

CPP, Cell-Penetrating Peptides

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Peptides for trans‐blood–brain barrier delivery

Cited by 7 publications

References 153 publications

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Methylene Blue-Doped Carbonized Polymer Dots: A Potent Photooxygenation Scavenger Targeting Alzheimer’s β-Amyloid

Potential of miRNA as Imaging Targets for PET

Therapeutic Potential of CPPs

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