Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo

Mechanisms of Neuroprotective Effects of Peptides Derived from Natural Materials and Their Production and Assessment

“…In the second step, there are associations between apoptosis and FasL, TNF‐ α, and TRAIL, which stimulate activation of caspase‐8 and the caspase‐3 pathway (Figure ). Numerous studies have reported death factors related to the apoptosis intrinsic pathway (Chai, Wu, Yang, Li, & Sun Pan, ; Chen et al., ; Li et al., ; Zhu, Guo, Guo, Peng, & Zhou, ). The peptide Met‐Gln‐Ile‐Phe‐Val‐Lys‐Thr‐Leu‐Thr‐Gly (MQIPVLTLTG) suppressed the release of cytochrome C and regulated expression of apoptosis‐related genes such as those encoding iNOS, Bax, and cleaved caspase‐3 (Kim et al., ).…”

“…The 11 peptides obtained from porcine cerebral hydrolysate caused remarkable improvement of spatial memory and escape latency, in addition to significantly reducing the production of ROS and MDA compared to Pb 2± ‐exposed mice (Zou et al., ). The Phe‐Tyr‐Tyr and Asp‐Trp peptides with antioxidant activity obtained from lantern fish hydrolysate were able to improve memory and learning deficiency of D‐galactose‐induced neurodegenerative ICR mice (Chai et al., ). The peptide‐fed mice had significantly lower levels of TBARS and endothelial NOS, and they showed higher levels of G6PDH and brain‐derived neurotrophy factor (BDNF, index of aging‐related learning and memory) (Chai et al., ).…”

“…Moreover, combinations of two or more enzymes may stimulate a higher degree of hydrolysis. Peptides with neuroprotective effects have been obtained from food proteins, including plant proteins (Chen et al., ; Jin et al., ; Li et al., ), meat proteins (Kim et al., ; Min et al., ; Wang et al., ), and marine proteins (Chai et al., ; Lin et al., ; Zhao et al., ). Li et al.…”

Emerging roles of bioactive peptides on brain health promotion

“…This increases oxidative stress, resulting in impairment of neurogenesis, memory loss, and neurodegeneration in mice. Hydrolysates of defatted walnut meal (Chen et al ., ), sea cucumber ( Cucumaria frondosa ; Lin et al ., ), and lantern fish ( Benthosema prerotum ; Chai et al ., ) reportedly improved learning and memory performance in D‐gal‐treated mice. The peptides WSREEQEREE and ADIYTRRAGR, and FYY and DW, which were identified from the hydrolysate of defatted walnut meal and lantern fish, respectively, effectively prevented oxidative stress‐induced neuronal cytotoxicity (Chai et al ., ), and these peptides are probably responsible for the memory‐enhancing effect (Table ).…”

Antioxidant hydrolyzed peptides from Manchurian walnut (Juglans mandshurica Maxim.) attenuate scopolamine‐induced memory impairment in mice

“…Animal tests showed that adding neuronal proteins and peptides that participate in cell–cell communication can activate and increase the number of new neurotransmitter receptor synapses in the hippocampus. The learning and memory abilities of mice were improved when these peptides were activated in the body …”