Peptides: Locally Active Peptides (“Vasoactive Peptides”)

Bertaccini, G.

doi:10.1007/978-3-642-68474-6_6

Mediators and Drugs in Gastrointestinal Motility II

1982

DOI: 10.1007/978-3-642-68474-6_6

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Peptides: Locally Active Peptides (“Vasoactive Peptides”)

G. Bertaccini¹

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Cited by 2 publications

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“…Despite the abundant literature in different smooth muscles, there are limited data on the effects of ANG II in the gastrointestinal smooth muscle that characterizes the mechanism and site(s) of excitatory effect, type of ANG II receptors, and receptor distribution (1,9). As it relates to the tonic smooth muscle of the gastrointestinal tract, studies (19) have been reported primarily in the lower esophageal sphincter (LES).…”

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Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action

Fan

Puri

Rattan

2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Effect of ANG II was investigated in in vitro smooth muscle strips and in isolated smooth muscle cells (SMC). Among different species, rat internal and sphincter (IAS) smooth muscle showed significant and reproducible contraction that remained unmodified by different neurohumoral inhibitors. The AT(1) antagonist losartan but not AT(2) antagonist PD-123319 antagonized ANG II-induced contraction of the IAS smooth muscle and SMC. ANG II-induced contraction of rat IAS smooth muscle and SMC was attenuated by tyrosine kinase inhibitors genistein and tyrphostin, protein kinase C (PKC) inhibitor H-7, Ca(2+) channel blocker nicardipine, Rho kinase inhibitor Y-27632 or p(44/42) mitogen-activating protein kinase (MAPK(44/42)) inhibitor PD-98059. Combinations of nicardipine and H-7, Y-27632, and PD-98059 caused further attenuation of the ANG II effects. Western blot analyses revealed the presence of both AT(1) and AT(2) receptors. We conclude that ANG II causes contraction of rat IAS smooth muscle by the activation of AT(1) receptors at the SMC and involves multiple intracellular pathways, influx of Ca(2+), and activation of PKC, Rho kinase, and MAPK(44/42).

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mentioning

confidence: 99%

Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action

Fan

Puri

Rattan

2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Angiotensin II stimulates human gastric smooth muscle in vitro

Lüdtke

Golenhofen

Schubert

1989

Journal of Autonomic Pharmacology

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1. For a precise analysis of angiotensin II (ANG) effects on human gastric muscle, we dissected longitudinal (lo) and circular (ci) strips from fundus (Fu), corpus (Co) and antrum (An), and circular muscle from the inner and outer part of the pyloric sphincter (Py-inn and Py-out) and from duodenum. The mechanical activity of these muscle strips was recorded simultaneously under auxotonic conditions. Preparations were taken from a total of 10 stomachs (from organ donors or gastrectomy preparations). 2. Excitatory effect after application of ANG (10(-9) to 10(-6) mol l-1) were regularly observed in all types of preparation (threshold: 10(-9) mol/l). 3. The quality of the responses depended on the general characteristics of the type of preparation. Tonic types of muscle showed predominantly tonic responses to ANG (Fu-lo, Fu-ci, Co-lo). Purely phasic muscles (An-ci) showed increases of the phasic activity (amplitude up to 33% delta 1). Intermediate types of muscle exhibited combined phasic/tonic responses (Co-ci, An-lo). Phasic responses were also seen in Py-out. Inner pyloric muscle (Py-inn) responded only to a small extent to ANG. Phasic/tonic activations were observed in the duodenal preparations, accompanied by slight increases in frequency. 4. The intensity of the ANG-induced responses often exceeded the maximum acetylcholine-induced activation. The qualitative pattern of ANG responses was similar to that of bombesin-induced activation.

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Peptides: Locally Active Peptides (“Vasoactive Peptides”)

Cited by 2 publications

References 73 publications

Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action

Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action

Angiotensin II stimulates human gastric smooth muscle in vitro

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