Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway

Jia, Yu; Gong, Nian; Li, Teng-Fei; Zhu, Bingquan; Wang, Yongxiang

doi:10.1016/j.phrs.2015.10.008

Cited by 34 publications

(52 citation statements)

References 55 publications

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“…After reviewing the full text of the remaining 158 papers, 80 studies were excluded because catalpol was not used as a monothrapy; 36 studies were excluded because the animal model was not acute focal cerebral ischemia; 11 studies were removed because the outcome measurement was neither NFS nor IV; 6 studies were excluded because they are duplicate publications. Ultimately, 25 eligible articles were identified [14–38] (Figure 2). …”

Section: Resultsmentioning

confidence: 99%

“…One study [23] got 2 points; 8 studies [16, 19, 20, 24, 28, 30, 34, 35] got 3 points; 11 studies [18, 21, 22, 25–27, 29, 32, 33, 36, 37] got 4 points; one study [15] got 5 points; 3 studies [17, 31, 38] got 6 points; one study [14] got 7 points (Table 1). The average score was 4.00.…”

Section: Resultsmentioning

confidence: 99%

“…One unpublished Ph.D. thesis was from Liu 2011 [23]. Seven studies described control of temperature [14, 16, 25, 27, 29, 31, 33]. Random allocation to treatment group was described in 21 studies [15, 17–24, 26–34, 36–38], and 2 studies used the method of random digit table [21, 33].…”

Section: Resultsmentioning

confidence: 99%

“…No study reported allocation concealment. Blinded assessment of outcome was described in 4 studies [14, 15, 17, 21, 22]. Twenty-one studies did not use anesthetics with significant intrinsic neuroprotective activity, and the remaining 4 studies did not report the type of anesthetics [15, 16, 23, 24].…”

Section: Resultsmentioning

confidence: 99%

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Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Zheng

Yang

Chen

et al. 2017

Oxidative Medicine and Cellular Longevity

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Neuroprotection is defined as using a therapy that affects the brain tissue in the still-viable ischemic penumbra to salvage or delay the infarction. Catalpol, the main active principle of the root of Radix Rehmanniae, was reported to have pleiotropic neuroprotective effects in neurodegenerative diseases including ischemic stroke. Here, we evaluated the neuroprotective effects of catalpol in experimental acute ischemic stroke. Studies on catalpol in animal models of acute ischemic stroke were identified from 6 databases. Twenty-five studies involving 805 animals were included. Twelve comparisons showed significant effects of catalpol on decreasing infarct size according to 2,3,5-triphenyltetrazolium chloride staining compared with the control (P < 0.05). One study reported significant effect of catalpol on reducing infarct size according to magnetic resonance imaging scan compared with the control (P < 0.05). Meta-analysis of these studies indicated that catalpol significantly improved the neurological function score according to Zea Longa score, Bederson score, balance beam-walking test, adhesive removal test, bar-grasping score, and corner test compared with the control (P < 0.05). In conclusion, catalpol exerted neuroprotective effects for experimental acute focal ischemic stroke, largely through reducing oxidative reactions, inhibiting apoptosis, and repressing inflammatory reactions and autophagy. However, these apparently positive findings should be interpreted with caution because of the methodological flaws.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Zheng

Yang

Chen

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Catalpol is one of the bioactive components of plantain (Al-Mamun et al, 2008a), which might be responsible for the insulin resistance. Because, the catalpol was found has the equal potentiality to work as like as GLP-1 receptor agonist (Jia et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Responses of plasma glucose metabolism to exogenous insulin infusion in sheep-fed forage herb plantain and exposed to heat

Al-Mamun

Shibuya

Kajita

et al. 2017

Animal

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The use of herbal plants as traditional medicines has a century long history. Plantain (Plantago lanceolata L.) is a perennial herb containing bioactive components with free radical scavenging activities. An isotope dilution technique using [U-13 C]glucose was conducted to determine the effect of plantain on the responses of plasma glucose metabolism to exogenous insulin infusion in sheep. Six crossbred sheep (three wethers and three ewes; mean initial BW = 40 ± 2 kg) were fed either a mixed hay of orchardgrass ( Dactylis glomerata) and reed canarygrass ( Phalaris arundinacea) (MH-diet) or mixed hay and fresh plantain (1 : 1 ratio, dry matter basis, PL-diet) and exposed to a thermoneutral (TN, 20°C; 70% relative humidity (RH)) environment or a heat exposure (HE, 30°C; 70% RH) for 5 days using a crossover design for two 23-day periods. The isotope dilution was conducted on days 18 and 23 of the experimental period during TN and HE, respectively. Plasma concentration of α-tocopherol was greater ( P < 0.0001) for the PL-diet than the MH-diet and remained comparable between environmental treatments. Plasma glucose concentration before isotope dilution technique was reduced for sheep ( P = 0.05) during HE compared with TN and remained comparable between diets. Plasma glucose turnover rate during the preinfusion period of insulin did not differ ( P = 0.10) between dietary treatments and between environments ( P = 0.65). The response of plasma glucose utilization to exogenous insulin administration was lower ( P = 0.04) for the PL-diet than the MH-diet. Under present experimental conditions, the plantain group was found to be resistant to the effects of insulin infusion.Keywords: glucose metabolism, plantain, insulin, heat stress, sheep Implications Plantain (Plantago lanceolata L.) is a perennial herb having bioactive components. The present experiment evaluated the effect of plantain on the responses of plasma glucose metabolism to exogenous insulin in heat-exposed sheep. Plasma glucose turnover rate (TR) was affected neither by feeding plantain nor exposure to a hot environment (30°C, 70% relative humidity (RH)). However, the response of plasma glucose utilization to exogenous insulin infusion was reduced in sheep when 50% of the mixed hay of orchardgrass (Dactylis glomerata) and reed canarygrass (Phalaris arundinacea) diet was replaced by fresh plantain.

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Antinociceptive glucagon-like peptides

Aykan

2022

The Neurobiology, Physiology, and Psychology of Pain

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Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway

Cited by 34 publications

References 55 publications

Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti‐Inflammation, and Antiapoptosis

Responses of plasma glucose metabolism to exogenous insulin infusion in sheep-fed forage herb plantain and exposed to heat

Antinociceptive glucagon-like peptides

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