Péptidos inmunogénicos del gluten en deposiciones. Nuevo método para evaluar la adherencia a la dieta en pacientes celíacos

Abstract

Celiac disease (CD) is an autoimmune pathology caused by the ingestion of gluten in genetically
 susceptible people, currently considered multisystemic. The treatment of CD is a lifelong strict
 Gluten-Free Diet (GFD), which allows a symptomatic improvement in most patients and achieve
 intestinal mucosa healing confirmed with histological study. The adherence to the GFD is
 variable, arguing as possible factors related to failure the economic, cultural, social aspects
 and the consumption of gluten inadvertently. The management of celiac patients contemplates
 instructing in the proper follow-up of GFD and evaluating their adherence. So far, the only way
 to assess adherence to GFD is through surveys, self-reports of eating habits and serology,
 being the main disadvantage the subjectivity factor. Recently the immunogenic gluten peptides
 have acquired relevance for the objective evaluation of the adherence to the GFD and the
 measurement appears as an efficient and sensitive option to determine the gluten intake,
 providing relevant information for the clinical management.