Peptoids as tools and sensors

Abstract

A review of molecular tools and sensors assembled on N‐substituted glycine, or α‐peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule sequestration and transport, (d) Peptoid sensors, (e) Macromolecule recognition, (f) Cellular transporters, (g) Medical imaging, (h) Future direction and (i) Summary and outlook. Peptoids are a promising class of peptide mimic making them an excellent platform for functional molecule preparation. Attributes of peptoid oligomers include: (a) the ease of precise sequence definition and mono‐dispersity; (b) access to a vast chemical space within simple and repeating chemical preparative steps and (c) thermal, chemical and biological stability all lending support for their application in a number of areas, with some that have been realised to date. The peptoid tool and sensor examples selected have realised practical utility. They serve to illustrate the rapidity of new insight that can generate in many disparate areas of science and technology, enabling the quick assembly of design criteria for efficient peptoid molecular tools and sensors.

Covalent flexible peptide docking in Rosetta

“…Such peptides can interact with their targets with high specificity and biologically relevant affinity. Although not typically compliant with Lipinski's rule of five [4] , recent chemical methodologies have been shown to improve pharmacokinetic properties of peptides, such as bioavailability, permeability and in vivo stability using tools such as N-methylation, cyclization and incorporation of D-amino acids [5][6][7][8] .…”

Stimulus-Responsive Polymers Based on Polypeptoid Skeletons

“…The temperature response can also be combined with the photo response [ 55 , 56 ]. These kinds of materials have a bright application prospect in the biocatalysis [ 57 ], drug carrier [ 58 ], coatings for protein adsorption [ 59 ], signal control of sensors and micro engines [ 60 ].…”

Bio-instructive materials on-demand – combinatorial chemistry of peptoids, foldamers, and beyond

“…Due to their modular assembly and sequence specificity, they find application in new materials design and materials science. 1,3,135,136 The class of peptoid materials comprises, i.e., bioinspired materials, metal chelators, and catalysts.…”