Per- and polyfluoroalkyl substances exposure and its influence on the intestinal barrier: An overview on the advances

Li, Jiaoyang; Wang, Lei; Zhang, Xin; Liu, Peng; Deji, Zhuoma; Xing, Yudong; Zhou, Yan; Lin, Xin; Huang, Zhenzhen

doi:10.1016/j.scitotenv.2022.158362

Cited by 19 publications

(11 citation statements)

References 156 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Notably, PFAS that remain in the digestive residue are not excreted directly. Gut microbes may interact with PFAS in digestive residues during the colonic phase, which may disturb both community homeostasis and metabolic homeostasis and adversely affect the intestinal mucosal barrier . Therefore, the behavior and toxic effects of PFAS in the lower gastrointestinal tract deserve further study.…”

Section: Resultsmentioning

confidence: 99%

Tracing the Bioaccessibility of Per- and Polyfluoroalkyl Substances in Fish during Cooking Treatment

Zhao,

Wang,

Zhang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Tracing the Bioaccessibility of Per- and Polyfluoroalkyl Substances in Fish during Cooking Treatment

Zhao,

Wang,

Zhang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

“…Regarding the distribution characteristics of PFAS, our study corroborates previous findings that PFAS accumulation tends to be higher in older individuals, which can be attributed to the longer half-life of PFAS [ 31 ], leading to their gradual build-up over time. Furthermore, a significant decrease in PFAS concentration was observed in females [ 32 ] potentially explained by factors such as menstrual blood loss or the influence of female hormones on the expression of organic anion transporters, which are involved in the kidney clearance and metabolism of PFAS [ 8 , 33 ]. In addition, our results indicate that PFAS accumulation is more likely to occur in individuals with low levels of daily physical activity, poor diet quality, and a history of former or current smoking.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, PFOA, PFOS, and PFHxS demonstrated a robust negative association with constipation. Previous studies have indicated that PFOA and PFOS have a high intestinal absorption index of over 90% in animal trials, while PFHxS can be almost completely absorbed from the intestine [ 8 ]. In our study, the negative correlation between PFOA and PFHxS with constipation persisted even after adjusting for multiple potential influencing factors in models A and B.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have suggested this possibility [ 36 , 41 – 43 ]. Notably, PFAS exposure has been reported to decrease the abundance of Dehalobacterium and Bacteroides [ 42 ], whereas a significant decrease in the firmicute / Bacteroides ratio is considered a key marker of intestinal dysbiosis [ 8 ]. Thus, PFAS exposure may potentially increase the Firmicute / Bacteroides ratio, serving as a protective factor in regulating constipation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005–2010)

Zhao,

Pu,

Zheng

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background The impact of per- and polyfluoroalkyl substances (PFAS) on constipation, as mediated through gastrointestinal absorption and perturbations to the intestinal microecology, remains poorly understood. Objective This study seeks to explain the relationship between PFAS and constipation. Methods A total of 2945 adults from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 were included in this study. Constipation was defined using the Bristol Stool Form Scale (BSFS) based on stool consistency. The relationship between PFAS and constipation was evaluated using weighted logistic regression and restricted cubic spline (RCS) analysis, while adjusting for confounding variables. Results The weighted median concentration of total PFAS (ΣPFAS) was significantly lower in individuals with constipation (19.01 μg/L) compared to those without constipation (23.30 μg/L) (p < 0.0001). Subgroup analysis revealed that the cumulative effect of PFAS was more pronounced in the elderly, men, individuals with obesity, high school education or equivalent, and high-income individuals (p < 0.05). After adjusting for confounding factors, multivariable analysis demonstrated an inverse association between PFOA [OR (95% CI), 0.666(0.486,0.914)] and PFHxS [OR (95% CI), 0.699(0.482,1.015)], and constipation. None of the personal and lifestyle factors showed a significant correlation with this negative association, as confirmed by subgroup analysis and interaction testing (p for interaction > 0.05). The RCS analysis demonstrated a linear inverse relationship between PFAS levels and constipation. Conclusion The findings of this study provide evidence of a significant inverse correlation between serum concentrations of PFAS, particularly PFOA and PFHxS, and constipation.

show abstract

“…For other gut bacteria, increases were found in: (1) phylum: Bacteroidetes and Proteobacteria; (2) family: Rikenellaceae and Ruminococcaceae; (3) genus: Bifidobacterium, Bilophila, Clostridium, Escherichia/Shigella, Gemella, Parabacteroides, Streptococcus, and Turicibacter; and (4) species: Bilophila wadsworthia, Faecalibacterium prautzii, Dorea longicatena, and Sutterella wadsworthensis in male mice. PFOS also disturbed the biosynthesis of flavonoid and steroid hormones, reducing the levels of both SCFAs and occludin, a tight junction protein [ 10 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ].…”

Section: Polyfluoroalkyl Substancesmentioning

confidence: 99%

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Jiang,

Guo

2024

Toxics

View full text Add to dashboard Cite

This review presents a new perspective on the exacerbation of autism spectrum disorder (ASD) by per- and polyfluoroalkyl substances (PFAS) through the gut–liver–brain axis. We have summarized evidence reported on the involvement of the gut microbiome and liver inflammation that led to the onset and exacerbation of ASD symptoms. As PFAS are toxicants that particularly target liver, this review has comprehensively explored the possible interaction between PFAS and acetaminophen, another liver toxicant, as the chemicals of interest for future toxicology research. Our hypothesis is that, at acute dosages, acetaminophen has the ability to aggravate the impaired conditions of the PFAS-exposed liver, which would further exacerbate neurological symptoms such as lack of social communication and interest, and repetitive behaviors using mechanisms related to the gut–liver–brain axis. This review discusses their potential interactions in terms of the gut–liver–brain axis and signaling pathways that may contribute to neurological diseases.

show abstract

Per- and polyfluoroalkyl substances exposure and its influence on the intestinal barrier: An overview on the advances

Cited by 19 publications

References 156 publications

Tracing the Bioaccessibility of Per- and Polyfluoroalkyl Substances in Fish during Cooking Treatment

Tracing the Bioaccessibility of Per- and Polyfluoroalkyl Substances in Fish during Cooking Treatment

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005–2010)

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Contact Info

Product

Resources

About