Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES

Graber, Judith M.; Alexander, Cora; Laumbach, Robert; Black, Kathleen; Ohman‐Strickland, Pamela; Georgopoulos, Panos G.; Marshall, Elizabeth G.; Shendell, Derek G.; Alderson, Donald; Mi, Zhongyuan; Mascari, Michael; Weisel, Clifford P.

doi:10.1038/s41370-018-0096-z

Cited by 92 publications

(70 citation statements)

References 25 publications

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“…A statistically significant and positive association between self-reported high cholesterol and PFNA exposure was observed, consistent with reports that other PFAS may affect blood lipid levels [292].…”

Section: Cholesterolsupporting

confidence: 90%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Section: Cholesterolsupporting

confidence: 90%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

Section: Cholesterolsupporting

confidence: 90%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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“…2014 ). Elevated concentrations of PFAS have been reported in the finished drinking water of community water systems that source water from areas with industrial facilities producing or using PFAS ( Graber et al. 2019 ; Hu et al.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

Kotlarz

McCord

Collier

et al. 2020

Environ Health Perspect

150

110

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Background: From 1980 to 2017, a fluorochemical manufacturing facility discharged wastewater containing poorly understood per- and polyfluoroalkyl substances (PFAS) to the Cape Fear River, the primary drinking water source for Wilmington, North Carolina, residents. Those PFAS included several fluoroethers including HFPO-DA also known as GenX. Little is known about the bioaccumulation potential of these fluoroethers. Objective: We determined levels of fluoroethers and legacy PFAS in serum samples from Wilmington residents. Methods: In November 2017 and May 2018, we enrolled 344 Wilmington residents of age into the GenX Exposure Study and collected blood samples. Repeated blood samples were collected from 44 participants 6 months after enrollment. We analyzed serum for 10 fluoroethers and 10 legacy PFAS using liquid chromatography–high-resolution mass spectrometry. Results: Participants’ ages ranged from 6 to 86 y, and they lived in the lower Cape Fear Region for 20 y on average (standard deviation: 16 y). Six fluoroethers were detected in serum; Nafion by-product 2, PFO4DA, and PFO5DoA were detected in of participants. PFO3OA and NVHOS were infrequently detected. Hydro-EVE was present in a subset of samples, but we could not quantify it. GenX was not detected above our analytical method reporting limit ( ). In participants with repeated samples, the median decrease in fluoroether levels ranged from 28% for PFO5DoA to 65% for PFO4DA in 6 months due to wastewater discharge control. Four legacy PFAS (PFHxS, PFOA, PFOS, PFNA) were detected in most ( ) participants; these levels were higher than U.S. national levels for the 2015–2016 National Health and Nutrition Examination Survey. The sum concentration of fluoroethers contributed 24% to participants’ total serum PFAS (median: ). Conclusion: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. Health implications of exposure to these novel PFAS have not been well characterized. https://doi.org/10.1289/EHP6837

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Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013–2014 NHANES

Cited by 92 publications

References 25 publications

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

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