Per Cent Absorbed Time Plots Derived from Blood Level and/or Urinary Excretion Data

Wagner, John G.; Nelson, Eino

doi:10.1002/jps.2600520629

Cited by 370 publications

(102 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Simplified procedures have been developed to overcome this problem. The Wagner-Nelson method (Wagner & Nelson, 1963) is based on an open one-compartment pharmacokinetic model, and estimates the rate but not the extent of absorption. If absorption obeys non-uniform kinetics, the method simply provides an absorption/time plot.…”

Section: Indirect Methodsmentioning

confidence: 99%

The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

Hirtz¹

1985

Brit J Clinical Pharma

108

View full text Add to dashboard Cite

show abstract

Section: Indirect Methodsmentioning

confidence: 99%

The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

Hirtz¹

1985

Brit J Clinical Pharma

108

View full text Add to dashboard Cite

show abstract

“…In some cases, when the Wagner Nelson equation is used, a flipflop model could exist (30,31), especially in case of SR formulations where the absorption rate is much lower than the elimination rate. In this case, the terminal decreasing of the plasma concentration curve, which normally reflects the elimination rate (ke), becomes a reflection of actual absorption rate (ka), while the initial increasing part of the curve, which normally reflects the absorption rate (ka), is the actual representation of the elimination rate (ke).…”

Section: Flip-flop Modelmentioning

confidence: 99%

In vitro–In Vivo Correlations: Tricks and Traps

Cardot

Davit

2012

AAPS J

View full text Add to dashboard Cite

Abstract. In vitro-in vivo correlation (IVIVC) is a biopharmaceutical tool recommended to be used in development of formulation. When validated, it can speed up development of formulation, be used to fix dissolution limits and also as surrogate of in vivo study. However, as do all tools, it presents limitations and traps. The aim of the present paper is to investigate five common traps which could limit either the setting or use of IVIVC (1) using mean or individual values; (2) correction of absolute bioavailability; (3) correction of lag time and time scaling; (4) flip-flop model; and (5) predictability corrections.

show abstract

“…Standard known methods [14], [15] were used for the estimation of various pharmacokinetic parameters.…”

Section: Estimation Of Pharmacokinetic Parametersmentioning

confidence: 99%

Preclinical Pharmacokinetic Evaluation of Captopril Floating Tablets Formualted Using Cross Linked Starch Urea - A New Modified Starch

Chowdary¹

2017

WJPPS

View full text Add to dashboard Cite

The objective of the present study is optimization of Captopril floating tablet formulation by 2 3 factorial design and to evaluate the optimized Captopril floating tablets for in vitro drug release, preclinical pharmacokinetics and also for in vitro -in vivo correlation (IVIVC).Captopril is an orally active anti-hypertensive drug, majorly absorbed from stomach and upper small intestine. Formulation of sustained release floating tablets of Captopril is needed because of its short biological half-life and instability at alkaline pH of intestines.Captopril floating tablets were formulated as per 2 3 factorial design and were evaluated. Captopril floating tablets prepared as per 2 3 factorial design were non-disintegrating in water and aqueous acidic (pH 1.2) and alkaline (pH 7.4) fluids and were of good quality with regard to drug content, hardness, friability and

show abstract

Per Cent Absorbed Time Plots Derived from Blood Level and/or Urinary Excretion Data

Cited by 370 publications

References 1 publication

The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.

In vitro–In Vivo Correlations: Tricks and Traps

Preclinical Pharmacokinetic Evaluation of Captopril Floating Tablets Formualted Using Cross Linked Starch Urea - A New Modified Starch

Contact Info

Product

Resources

About