In relation to innovations which help to cope with the COVID-19 pandemic, the best practices of several smart cities become an important input to organize and create strategies for future cities. This research aims to identify the responses of cities to the COVID-19 pandemic; analyze their innovation in tackling the COVID-19 pandemic; and create strategies and planning for the future of the cities. This study analyzes aspects such as the use of information and communication technology (ICT), smart city implementation, the biological disaster of the COVID-19 pandemic, the environment, and spatial plans. This research was carried out in five smart cities using a case study. The results indicated that each case had innovations for coping with the COVID-19 pandemic. They showed a uniqueness and local innovations adapted to the problems faced in the five case areas. The innovations were demonstrated by the use of ICT-based applications in several public services as part of smart city implementation. The concept of a smart city, which addresses the biological disaster of the COVID-19 pandemic through the existence of ship-based isolation centers and sociotechnical innovations, was then adapted in various cities throughout Indonesia. In terms of the smart environment concept, this is translated through technological and social innovation approaches to improve medical and domestic waste management, public service systems, and the socialization of environmental protection programs in cities during the pandemic. The COVID-19 pandemic is allegedly accelerating the implementation of the smart city concept in spatial planning. There is a tendency for the use of public space in the city center to shift to local-scale service centers. Additionally, other activities are increasingly occupying the digital space so that it affects the arrangement of spatial organization and increases the need for ICT infrastructure. The efficient and flexible use of applications for supporting the implementation of smart cities needs to be broadened for the public services provided by both the government and private sectors. Meanwhile, in relation to the dimensions of a smart environment, it is necessary to take into account the waste management as a result of COVID-19. The same case is the aspect of spatial planning in which it is necessary to redesign open spaces for public use. City planning in the future also needs to be capable of the smart mitigation of non-physical disasters, such as the COVID-19 pandemic.