Perbedaan derajat disfungsi ereksi pada pasien penyakit ginjal kronik derajat 5 sebelum dan setelah menjalani continuous ambulatory peritoneal dialysis

Winarta, Gede Kesuma; Duarsa, Gede Wirya Kusuma; Kandarini, Yenny

doi:10.15562/medicina.v51i3.800

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study by Winarta et al showed that the severity of DE was assessed by IIEF5 questionnaire after being diagnosed with stage 5 CKD, by which mild-to-moderate ED in 13 people (59.1%) was found. 13 Azevedo et al conducted a study on 30 patients undergoing HD in Porto, Portugal, in 2012, and found a high prevalence of severe ED before CAPD therapy (up to 93.3%). Even more, there was change in degree of severe erectile dysfunction to 44.8% after receiving dialysis using CAPD.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Male Erectile Dysfunction Characteristics in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and Hemodialysis Using the International Index of Erectile Function (IIEF-5) Combined with Hospital Anxiety and Depression Scales

Warli¹,

Alamsyah²,

Nasution³

et al. 2023

IJNRD

View full text Add to dashboard Cite

Purpose To determine the differences in mean scores of erectile dysfunctions (EDs) assessed by the International Index of Erectile Function (IIEF-5) questionnaire between patients with chronic kidney disease (CKD) undergoing hemodialysis and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Patients and Methods This is an analytic observational study with a cross-sectional design that was conducted from June to December 2022 at the Urology Center of Haji Adam Malik General Hospital and Rasyida Kidney Specialized Hospital. The sample of this study were male CKD-patients who underwent regular hemodialysis (HD) and who underwent CAPD, and met the inclusion and exclusion criteria. Psychological disorders experienced during therapy session are considered as risk factors and assessed via the Hospital Anxiety and Depression Scale (HADS). These disorders assessment was used to evaluate the severity of the patients’ anxiety and depressive symptoms. Statistical data analysis was carried out. Results Both groups had HADS-A and HADS-D scores with an average <7, classified as normal anxiety and depression. Most of the patients in the HD group had mild-to-moderate ED (28.6%), while in the CAPD group had mild severity of ED (38.1%). There were no significant differences in severity of ED between patients undergoing HD and CAPD (p > 0.05). However, there was a significant difference in ED scores (IIEF-5) between patients undergoing HD and those with CAPD (p < 0.05), in which patients in the CAPD group had a higher IIEF-5 score. In addition, there was a significant positive correlation with moderate strength (p<0.001; r =0.494) between anxiety disorders and ED disorders in patients undergoing HD and CAPD, whereas there is no significant correlation between depressive disorders and ED conditions (p > 0.05). Conclusion There was a significant difference in IIEF-5 scores between patients undergoing HD and CAPD.

show abstract

Section: Discussionmentioning

confidence: 99%

The Assessment of Male Erectile Dysfunction Characteristics in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and Hemodialysis Using the International Index of Erectile Function (IIEF-5) Combined with Hospital Anxiety and Depression Scales

Warli¹,

Alamsyah²,

Nasution³

et al. 2023

IJNRD

View full text Add to dashboard Cite

show abstract

“…Sexual dysfunction is the inability to achieve satisfactory sexual intercourse in the form of erectile dysfunction (ED), reduced libido, and abnormal ejaculation (Sin et al, 2020). DE is the sexual dysfunction disorder with the highest prevalence, this state can affect emotional and physical self-esteem, psychosocial conditions such as depression, anxiety, and quality of life disorders (Kazemi et al, 2021) and a significant impact on the quality of life of sufferers (Winarta et al, 2020). The prevalence of ED in men aged 40-75 years was 52%, and mild, moderate, and complete DE was 2.17%, 2.25%, and 6.9%, respectively (Maleki-Saghooni et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Active Compounds of Herbal Plants as Aphrodisiacs Through Molecular Docking Against Human Phosphodiesterase-5 Receptors

Indratmoko¹,

Nurani

Wahyuningsih

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

View full text Add to dashboard Cite

Based on the evaluation of side effects the use of sildenafil as a human phosphodiesterase 5 inhibitor drug (HPDE5) has prompted the search for new compounds that have the potential to be aphrodisiacs. The purpose of this study was to determine the interaction of the active compounds nilocitin, stigmasterol, protodioscin, icariin, yohimbine, and ginsenoside against the HPDE5 receptor as an aphrodisiac. The method used in this study was experimental conducted in silico. The metabolite structure is downloaded from the PubChem application, the protein is downloaded from PDB (Protein Data Bank) with the code 2H42. The result of this study is that the active compound may interact with HPDE5 receptors. The interaction that occurs results in the formation of van der waals bonds, hydrogen, carbon hydrogen, sigma, sulfur cation anions, T-shape and alkyls. The active compounds each have a sildenafil bond energy of -9.5 kcal/mol; niloticin -7.8 kcal/mol; stigmasterol -10.7 kcal/mol; protodioscin -13.1 kcal/mol; icariin -11.1 kcal/mol; yohimbine -10.1 kcal/mol and ginsenoside -12.1 kcal/mol with RMSD 0. The interaction with the HPDE5 receptor results in the formation of the same amino acid residue as the comparison ligand. The residual equation shows that the compounds have the same activity and can be predicted as aphrodisiacs

show abstract

Perbedaan derajat disfungsi ereksi pada pasien penyakit ginjal kronik derajat 5 sebelum dan setelah menjalani continuous ambulatory peritoneal dialysis

Cited by 2 publications

References 0 publications

The Assessment of Male Erectile Dysfunction Characteristics in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and Hemodialysis Using the International Index of Erectile Function (IIEF-5) Combined with Hospital Anxiety and Depression Scales

The Assessment of Male Erectile Dysfunction Characteristics in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis and Hemodialysis Using the International Index of Erectile Function (IIEF-5) Combined with Hospital Anxiety and Depression Scales

Effectiveness of Active Compounds of Herbal Plants as Aphrodisiacs Through Molecular Docking Against Human Phosphodiesterase-5 Receptors

Contact Info

Product

Resources

About