Perceived Cognition after Percutaneous Coronary Intervention: Association with Quality of Life, Mood and Fatigue in the THORESCI Study

Abstract

PurposePercutaneous coronary intervention (PCI) is a common invasive procedure for the treatment of coronary artery diseases. Long-term cognitive functioning after PCI and its association with health-related quality of life (HRQL) and psychological factors is relatively unknown. The aim of this study is to examine whether perceived cognitive functioning during the year after PCI is associated with HRQL over this time period, and whether mood, fatigue, and age are associated with changes in perceived cognition and HRQL.MethodsPatients undergoing PCI (n = 384, 79% male, mean age = 63, SD = 10) were recruited in the observational Tilburg Health Outcome Registry of Emotional Stress after Coronary Intervention (THORESCI) cohort study. Perceived concentration and attention problems, HRQL, mood, and fatigue were assessed at baseline, at 1-month and 12-month follow-up.ResultsGeneral linear mixed modeling analysis showed that across time, between- and within-subject differences in perceived concentration problems were associated with a reduced HRQL in all domains independent of clinical and demographic covariates. Only a part of this association could be explained by negative mood, fatigue, and older age. Similar findings were found for between-subject differences in perceived attention problems.ConclusionsBetween-subject differences and within-subject changes in perceived cognition in PCI patients were strongly associated with HRQL across time, such that poorer perceived cognition was associated with poorer HRQL, independent of demographic and clinical variables. Most of the associations were also independent of mood and fatigue. The results should increase the awareness of clinicians for the role of cognition in the cardiac rehabilitation and recovery post-PCI.

Self-Reported Cognitive Function in Persons with Nonneurological Chronic Diseases: A Systematic Review

“…The remaining studies ranged from measuring one domain (e.g., only executive function) [ 23 , 39 ] to seven domains [ 26 ]. Ten studies [ 21 , 25 , 28 , 31 , 32 , 36 , 37 , 44 , 48 , 51 ] reported reliability of the SCRF tools with Cronbach's alphas ranging from .67 to .8 for the Health Complaints Scale–Concentration subscale to .96 for the Cognitive Difficulties Scale. Items on each tool ranged from three [ 39 ] to 95 [ 21 ].…”

“…A number of additional patient-reported outcomes were associated with SRCF in samples with various nonneurologic chronic conditions. Two studies reported findings from separate samples undergoing interventions for cardiovascular disease—percutaneous coronary interventions (PCIs) and coronary artery bypass surgery (CABG) [ 28 , 31 ]. For those undergoing PCI, poorer perceived cognitive function was associated with poorer quality of life independently of demographics, fatigue, mood, and other clinical variables [ 28 ].…”

“…Two studies reported findings from separate samples undergoing interventions for cardiovascular disease—percutaneous coronary interventions (PCIs) and coronary artery bypass surgery (CABG) [ 28 , 31 ]. For those undergoing PCI, poorer perceived cognitive function was associated with poorer quality of life independently of demographics, fatigue, mood, and other clinical variables [ 28 ]. In the sample undergoing CABG, baseline cognitive complaints predicted a higher rate of negative emotional symptoms at 5 months [ 31 ].…”

Cognitive function in patients with coronary artery disease: A literature review

“…20 Moreover, accelerated cognitive decline has been linked to dementia 21 and reduced quality of life. 22 Studies examining the cognitive function of patients with CAD are encouraged to better identify individuals at high risk for cognitive decline. 23 It is also important to determine which factors may be associated with cognitive function in this particular population.…”

Reaction Time and Anticipatory Skill in Patients Undergoing Percutaneous Coronary Intervention Compared With Normal Controls: A Pilot Study

“…Artery Disease (CAD) is one of the most common forms of cardiovascular diseases, which is a leading cause of mortality, dis-ability, low quality of life, and a financial burden [1,2]. In addition, several studies have reported that Cognitive Impairment (CI) is a prevalent dysfunction in CAD patients [3][4][5].…”