This study uses a range of variables that can affect the likelihood of deviant conduct among employees in the workplace to contribute to workplace deviance. This study aims to investigate, using Social Exchange Theory as a framework, the effects of Workplace Deviant Behavior on Organizational Commitment, Workplace Spirituality, Ethical Leadership, Organizational Justice, and Job Satisfaction. This research is a quantitative research using the sample quota technique used as a non-random sample method based on the quota set by the researcher. This study had 432 respondents, with 216 employees from 3 Islamic Universities in Purwokerto City calculated with regard to a 5% margin of error when applying the Slovin formulaand the results reached 208 people. In this study, hardfile and softfile questionnaire questionnaires (Google fromulir) were used in research sampling. Data collection using Likert scale-based questionnaire, then data tested using Smart PLS Application. The results showed that although Organizational Commitment and Woekplace Spirituality showed a direct negative influence, it was not significant on Workplace Deviant Behavior. Conversely, Workplace Deviant Behavior is negatively but significantly influenced by Organizational Justice and Job Satisfaction. Furthermore, there is a minor but favorable correlation between ethical leadership and workplace deviant behavior.