Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data

Li, Guangfei; Chen, Yu; Le, Thang M.; Zhornitsky, Simon; Wang, Wuyi; Dhingra, Isha; Zhang, Sheng; Tang, Xiaoying; Li, Chiang‐Shan R.

doi:10.1016/j.drugalcdep.2021.108731

Cited by 17 publications

(13 citation statements)

References 120 publications

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“…For example, in a study of university students, researchers found that students who reported a high number of people who they could rely on for support in stressful times consumed a lower quantity of alcohol during a stressful period (i.e., class examinations) relative to students who reported a lower number of such contacts ( Steptoe et al, 1996 ). Moreover, recent work suggests that time spent with peers and higher perceived friendship, measured by the perceived availability of friends with whom to interact, is related to increased consumption of alcohol among college-aged students ( Gesualdo and Pinquart, 2021 ; Li et al, 2021 ). The importance of quality of peer support vs. quantity of peer affiliation may be key in parsing the effect of peer-derived social support on alcohol use in young adults.…”

Section: Social Support and Alcohol Use In Adulthoodmentioning

confidence: 99%

Gender Differences in the Psychosocial Determinants Underlying the Onset and Maintenance of Alcohol Use Disorder

et al. 2022

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A large number of different mechanisms have been linked to Alcohol Use Disorder (AUD), including psychosocial, neurocognitive, affective, and neurobiological factors. Gender has been shown to impact the presentation and progression of AUD; yet, little work has been done to parse the different mechanisms underlying AUD within the lens of gender differences. A review of the literature on adolescence revealed that psychosocial factors, in particular lack of family social support and interactions with peers, drive the onset of alcohol use more strongly in girls relative to boys. However, research done on gender differences in disease progression in adults remains limited. Our gender-specific analysis of the mechanisms underlying AUD in adults revealed that lack of social support was causally linked to negative affect, mental health symptoms, and AUD symptom severity in women, but not men. These novel results suggest that psychosocial factors may play a gender-specific role not only in the onset of use in adolescence, but also in the maintenance of addiction in adults. If confirmed, this suggests the need for investigating gender-specific recovery trajectories. In this perspective piece, we review the literature regarding gender differences in the onset and maintenance of AUD and present original data that support unique risk factors in women.

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Section: Social Support and Alcohol Use In Adulthoodmentioning

confidence: 99%

Gender Differences in the Psychosocial Determinants Underlying the Onset and Maintenance of Alcohol Use Disorder

et al. 2022

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“… Zimmermann et al (2019) N = 47 ( n = 23 cannabis) M age = 23.76 (3.12) 100 % Male Self-report Effects of substance use on neural function Cannabis Interpersonal Touch Paradigm Touch > Close Female > Male Striatum, insula Cannabis users showed less activity in the dorsal striatum with female experimenter touch, while non-users showed more striatal activity during interpersonal touch. Li et al (2021) N = 460 (Human Connectome Project) M age = 28.75 (3.6) 51.7 % Female Self-report, perceived friendship Effects of substance use on neural function Alcohol Social Cognition Task (shapes interacting either socially or randomly) Social Interaction of abstract shapes > Non-Social Right posterior insula, mOFC, left ventral precuneus Binge drinkers, especially female, had less response in the mOFC and precuneus to social interactions of abstract shapes compared to random movement. Greater posterior insula activity was correlated with lower self-reported scores on perceived friendships.…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, one study used non-social stimuli (i.e., abstract shapes) to study neural response to socially-imbued interactions in relation to substance use. Participants in the Human Connectome Project (HCP) completed a task involving watching shapes interact, either in a pattern representing social interaction, or a pattern of random movement ( Li et al, 2021 ). Binge drinkers aged 22–36 demonstrated less response in the mOFC and precuneus to social interactions among shapes.…”

Section: Resultsmentioning

confidence: 99%

The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood

Beard

Yoon

Venticinque

et al. 2022

Developmental Cognitive Neuroscience

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“…Imaging studies have characterized altered regional brain responses to cognitive challenges in binge drinkers. For instance, a recent study showed lower activation of the anterior medial orbitofrontal cortex (OFC) in binge relative to nonbinge drinkers during perception of social vs. random interaction, with OFC activities contributing to perceived friendship and the severity of alcohol use 3 . Higher activation of the ventral striatum (VS) and ventromedial prefrontal cortex during risk‐taking has been shown to predict earlier onset of binge drinking 4 .…”

Section: Psychological and Neural Features Of Binge Drinkingmentioning

confidence: 99%

“…For instance, a recent study showed lower activation of the anterior medial orbitofrontal cortex (OFC) in binge relative to nonbinge drinkers during perception of social vs. random interaction, with OFC activities contributing to perceived friendship and the severity of alcohol use. 3 Higher activation of the ventral striatum (VS) and ventromedial prefrontal cortex during risk-taking has been shown to predict earlier onset of binge drinking. 4 In addition, higher OFC and VS activation during exposure to alcohol cues has been associated with alcohol use severity in college students.…”

Section: Psychological and Neural Features Of Binge Drinkingmentioning

confidence: 99%

Cognitive Challenges Are Better in Distinguishing Binge From Nonbinge Drinkers: An Exploratory Deep‐Learning Study of fMRI Data of Multiple Behavioral Tasks and Resting State

Zhang

Chen

et al. 2022

Magnetic Resonance Imaging

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Background Studies have identified imaging markers of binge drinking. Functional connectivity during both task challenges and resting state was shown to distinguish binge and nonbinge drinkers. However, no studies have compared the efficacy of task and resting data in the classification. Hypothesis Task outperforms resting‐state functional magnetic resonance imaging (fMRI) data in the differentiation of binge and nonbinge drinkers. We tested the hypothesis via multiple deep learning algorithms. Study Type Cross‐sectional; retrospective. Population A total of 149 binge (107 men) and 151 demographically matched, nonbinge (92 men) drinkers curated from the Human Connectome Project, with 80% randomly selected for model development and 20% for validation/test. Field Strength/Sequence A 3 T; fMRI with a blood oxygen level‐dependent (BOLD) gradient‐echo echo‐planar sequence. Assessment FMRI data of resting state and seven behavioral tasks were acquired. Graph convolutional network (GCN), long short‐term memory, convolutional, and recurrent neural network models were built to distinguish bingers and nonbingers using connectivity matrices of 8, 116, and 268 regions of interest (ROI). Nodal metrics including betweenness centrality, degree centrality, clustering coefficient, efficiency, local efficiency, and shortest path length were calculated from the GCN model. Statistical Tests Model performance was quantified by the area under the curve (AUC) in receiver operating characteristic analysis. A P value < 0.05 was considered statistically significant. Results Task outperformed resting data in classification by approximately 8% by AUC in the test set. Across models and ROI sets, the gambling, motor, language and working memory tasks, each with AUC of 0.614, 0.612, 0.605, and 0.603, performed better than resting data (AUC = 0.548). Models with 116 ROIs (AUC = 0.602) consistently outperformed those with 8 ROIs (AUC = 0.569). Task data performed best with GCN (AUC = 0.619). Nodal metrics of left supplementary motor area and right cuneus showed significant group main effect across tasks. Conclusion Neural responses to cognitive challenges relative to resting state better characterize binge drinking. The performance of different network models may depend on behavioral tasks and the number of ROIs. Evidence Level 3 Technical Efficacy Stage 2

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Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data

Cited by 17 publications

References 120 publications

Gender Differences in the Psychosocial Determinants Underlying the Onset and Maintenance of Alcohol Use Disorder

Gender Differences in the Psychosocial Determinants Underlying the Onset and Maintenance of Alcohol Use Disorder

The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood

Cognitive Challenges Are Better in Distinguishing Binge From Nonbinge Drinkers: An Exploratory Deep‐Learning Study of fMRI Data of Multiple Behavioral Tasks and Resting State

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