Perceived Intensity and Pleasantness of Sucrose Taste in Male Alcoholics

Wroński, Michał; Skrok-Wolska, Dominika; Samochowiec, Jerzy; Ziółkowski, Marcin; Święcicki, Łukasz; Bieńkowski, Przemysław; Korkosz, Agnieszka; Zatorski, Paweł; Kukwa, Wojciech; Ścińska, Anna

doi:10.1093/alcalc/agl097

Cited by 34 publications

(35 citation statements)

References 41 publications

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“…A tendency to prefer more concentrated sweet solutions has been found across several different forms of psychopathology characterized by dysfunctional reward processing, including eating disorders and substance use disorders (Kampov-Polevoy, Eick, Boland, Khalitov, & Crews, 2006; Kampov-Polevoy, Garbutt, Davis, & Janowsky, 2006; Kampov-Polevoy, Tsoi, Zvartau, Neznanov, & Khalitov, 2001; Kampov-Polevoy, Ziedonis, et al, 2006; Krahn et al, 2006; Wronski et al, 2007). The processing of sweet taste involves two distinct neural pathways: (1) a taste detection/discrimination pathway extending from the thalamus to the primary gustatory cortex, and (2) a taste hedonic processing pathway extending from the thalamus to the limbic system and other reward-related brain regions (Hajnal & Norgren, 2005; Kosar, Grill, & Norgren, 1986; Reilly, Grigson, & Norgren, 1993).…”

Section: Introductionmentioning

confidence: 99%

Intact hedonic responses to sweet tastes in autism spectrum disorder

Damiano

Aloi

Burrus

et al. 2014

Research in Autism Spectrum Disorders

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The Sweet Taste Test (STT) is a standardized measure designed to index the ability to detect differences in sweet tastes (sweet taste sensitivity) and hedonic responses to sweet tastes (sweet taste liking). Profiles of response on the STT suggest enhanced hedonic responses to sweet tastes in psychiatric disorders characterized by dysfunctional reward processing systems, including binge-eating disorders and substance use disorders, and a putative mechanism governing STT responses is the brain opioid system. The present study examined STT responses in 20 adults with autism spectrum disorder (ASD) and 38 healthy control adults. There were no differences in sweet taste sensitivity or hedonic response to sweet tastes between the ASD and control groups. Within the ASD sample, ASD symptom severity was associated with sweet taste sensitivity, but not hedonic response to sweet taste. Results may ultimately shed light on brain opioid system functioning in ASD.

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Section: Introductionmentioning

confidence: 99%

Intact hedonic responses to sweet tastes in autism spectrum disorder

Damiano

Aloi

Burrus

et al. 2014

Research in Autism Spectrum Disorders

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“…For example, HiS rats (vs LoS rats) acquire ethanol (Dess et al, 1998), heroin, and cocaine self-administration at increased rates and show greater cocaine-induced locomotor activity (Carroll et al, 2007a). As sweet preference is positively related to drug abuse in humans (Janowsky et al, 2003; Wronski et al, 2007), this animal model of differential vulnerability allows us to investigate genetic factors during key phases of the drug abuse process, such as escalation.…”

Section: Introductionmentioning

confidence: 99%

Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake

Anker

Holtz

Carroll

2012

Behavioural Pharmacology

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Progesterone decreases cocaine self-administration in women and in female rats. In a previous study using rats selectively bred for high (HiS) and low (LoS) saccharin intake, HiS rats escalated their cocaine intake compared to LoS rats. Our goal was to examine the effects of progesterone on the escalation of cocaine self-administration in HiS and LoS rats. Four groups of female rats were compared: HiS P (progesterone-treated), LoS P, HiS VEH (vehicle-treated), and LoS VEH. Rats were trained to self-administer 0.8 mg/kg cocaine i.v. under a fixed-ratio 1 (FR 1) schedule during daily short-access (ShA) 2-h sessions. Rats then self-administered 3 randomly-presented doses of cocaine (0.2, 0.4, 1.6 mg/kg) and then had daily 6-h long-access (LgA) sessions with 0.4 mg/kg cocaine for 21 days. Cocaine intake was then reassessed with the 4 doses under the ShA condition. Throughout the experiment, rats were treated with daily s.c. injections of P (0.5 mg/kg) or an equal volume of VEH 30 min prior to each session. During the initial ShA condition, HiS rats earned more cocaine infusions than LoS rats at all doses, and during the subsequent LgA condition, HiS rats escalated cocaine intake, while the LoS rats maintained a steady rate. Progesterone treatment potentiated escalation of cocaine intake in the HiS rats but had an opposite effect on LoS rats, attenuating their cocaine self-administration. Results from the post-LgA dose-response ShA condition, indicated that both LoS and HiS VEH and P-treated rats earned more infusions than pre-LgA, but mainly at low doses. These results suggest that genetic differences in drug abuse vulnerability contribute differentially to treatment outcomes during escalation, a critical phase of the drug abuse process.

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“…2003; Mennella et al . 2010; Pepino & Mennella 2007; Wronski et al . 2007) and supports this phenotype as a potential biomarker for vulnerability to alcoholism involving a familial or genetic component.…”

Section: Discussionmentioning

confidence: 99%

“…2010), the first brain area to receive and process taste information. In humans, genetic risk for alcoholism as indexed by a positive family history of the disorder has repeatedly been associated with heightened preference for concentrated sweet solutions (Kampov-Polevoy, Garbutt & Khalitov 2003; Pepino & Mennella 2007; Wronski et al . 2007).…”

Section: Introductionmentioning

confidence: 99%

Chemosensory responsiveness to ethanol and its individual sensory components in alcohol‐preferring, alcohol‐nonpreferring and genetically heterogeneous rats

et al. 2011

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Alcohol activates orosensory circuits that project to motivationally relevant limbic forebrain areas that control appetite, feeding and drinking. To date, limited data exists regarding the contribution of chemosensory-derived ethanol reinforcement to ethanol preference and consumption. Measures of taste reactivity to intra-orally infused ethanol have not found differences in initial orofacial responses to alcohol between alcohol-preferring (P) and – nonpreferring (NP) genetically selected rat lines. Yet, in voluntary intake tests P rats prefer highly-concentrated ethanol upon initial exposure, suggesting an early sensory-mediated attraction. Here, we directly compared self-initiated chemosensory responding for alcohol and prototypic sweet, bitter, and oral trigeminal stimuli among selectively bred P, NP, and non-selected Wistar (WI) outbred lines to determine whether differential sensory responsiveness to ethanol and its putative sensory components are phenotypically associated with genetically-influenced alcohol preference. Rats were tested for immediate short-term lick responses to alcohol (3–40%), sucrose (0.01–1 M), quinine (0.01–3 mM) and capsaicin (0.003–1 mM) in a brief-access assay designed to index orosensory-guided behavior. P rats exhibited elevated short-term lick responses to both alcohol and sucrose relative to NP and WI lines across a broad range of concentrations of each stimulus and in the absence of blood alcohol levels that would produce significant postabsorptive effects. There was no consistent relationship between genetically-mediated alcohol preference and orosensory avoidance of quinine or capsaicin. These data indicate that enhanced initial chemosensory attraction to ethanol and sweet stimuli are phenotypes associated with genetic alcohol preference and are considered within the framework of downstream activation of oral appetitive reward circuits.

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Perceived Intensity and Pleasantness of Sucrose Taste in Male Alcoholics

Abstract: The present results suggest the following: (i) alcohol dependence is not associated with any major alterations in taste responses to sucrose solutions, (ii) sweet liking is a phenotypic marker of male alcoholics with a paternal history of alcoholism.

Cited by 34 publications

References 41 publications

Intact hedonic responses to sweet tastes in autism spectrum disorder

Intact hedonic responses to sweet tastes in autism spectrum disorder

Effects of progesterone on escalation of intravenous cocaine self-administration in rats selectively bred for high or low saccharin intake

Chemosensory responsiveness to ethanol and its individual sensory components in alcohol‐preferring, alcohol‐nonpreferring and genetically heterogeneous rats

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