Perceived Occupational Stress is associated with Decreased Cortical Activity of the Prefrontal Cortex: A Multichannel Near-infrared Spectroscopy Study

Chou, Po-Han; Lin, Wei; Hung, Chao An; Chang, Chiung Chih; Li, Wan Rung; Lan, Tsuo Hung; Huang, Min

doi:10.1038/srep39089

Cited by 29 publications

(13 citation statements)

References 59 publications

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“…These findings suggest that dlPFC activity has a significant impact on the regulation of the ANS and perceived stress. The present findings are consistent with prior studies that have demonstrated the dlPFC supports emotional processes important to the stress response (Critchley et al, 2001; Chou et al, 2016; Dedovic et al, 2009). Specifically, the present study suggests that the dlPFC modulates important components of the emotional response (ANS and perceived stress) to stress.…”

Section: Discussionsupporting

confidence: 93%

Amygdala and prefrontal cortex activity varies with individual differences in the emotional response to psychosocial stress.

Orem

Wheelock

Goodman

et al. 2019

Behavioral Neuroscience

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Stress elicits a variety of psychophysiological responses that show large interindividual variability. Determining the neural mechanisms that mediate individual differences in the emotional response to stress would provide new insight that would have important implications for understanding stress-related disorders. Therefore, the present study examined individual differences in the relationship between brain activity and the emotional response to stress. In the largest stress study to date, 239 participants completed the Montreal Imaging Stress Task (MIST) while heart rate, skin conductance response (SCR), cortisol, self-reported stress, and blood oxygen level dependent (BOLD) functional MRI (fMRI) signal responses were measured. The relationship between differential responses (heart rate, SCR, cortisol, and self-reported stress) and differential BOLD fMRI data was analyzed. Dorsolateral prefrontal cortex (PFC), dorsomedial PFC, ventromedial PFC, and amygdala activity varied with the behavioral response (i.e., SCR and self-reported stress). These results suggest the PFC and amygdala support processes that are important for the expression and regulation of the emotional response to stress, and that stress-related PFC and amygdala activity underlie interindividual variability in peripheral physiologic measures of the stress response.

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Section: Discussionsupporting

confidence: 93%

Amygdala and prefrontal cortex activity varies with individual differences in the emotional response to psychosocial stress.

Orem

Wheelock

Goodman

et al. 2019

Behavioral Neuroscience

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“…Therefore, the analyzed PI data should be interpreted with caution. Sixth, we excluded 9.1% rejected channels for accurate data analysis, this rejected proportion is similar to the previous study 58 . Seventh, we excluded 34 patients (48.6%) with bilateral stenosis or poor NIRS signals.…”

Section: Discussionsupporting

confidence: 69%

The slope of cerebral oxyhemoglobin oscillation is associated with vascular reserve capacity in large artery steno-occlusion

Kim

Park

et al. 2021

Sci Rep

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Inadequate cerebral perfusion is a risk factor for cerebral ischemia in patients with large artery steno-occlusion. We investigated whether prefrontal oxyhemoglobin oscillation (ΔHbO2, 0.6–2 Hz) was associated with decreased vascular reserve in patients with steno-occlusion in the large anterior circulation arteries. Thirty-six patients with steno-occlusion in the anterior circulation arteries (anterior cerebral artery, middle cerebral artery, and internal carotid artery) were included and compared to thirty-six control subjects. Patients were categorized into two groups (deteriorated vascular reserve vs. preserved vascular reserve) based on the results of Diamox single- photon emission computed tomography imaging. HbO2 data were collected using functional near-infrared spectroscopy. The slope of ΔHbO2 and the ipsilateral/contralateral slope ratio of ΔHbO2 were analyzed. Among the included patients (n = 36), 25 (69.4%) had deteriorated vascular reserve. Patients with deteriorated vascular reserve had a significantly higher average slope of ΔHbO2 on the ipsilateral side (5.01 ± 2.14) and a higher ipsilateral/contralateral ratio (1.44 ± 0.62) compared to those with preserved vascular reserve (3.17 ± 1.36, P = 0.014; 0.93 ± 0.33, P = 0.016, respectively) or the controls (3.82 ± 1.69, P = 0.019; 0.94 ± 0.29, P = 0.001). The ipsilateral/contralateral ΔHbO2 ratio could be used as a surrogate for vascular reserve in patients with severe steno-occlusion in the anterior circulation arteries.

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“…Moreover, fNIRS provides a bedside measurement of oxy-hemoglobin (oxy-Hb) and deoxy-hemoglobin (deoxy-Hb) concentrations, which are thought to indicate regional cerebral blood volumes and show strong correlations with fMRI signals [83]. Following this principle, fNIRS may be applicable to some of the unique research problems associated with neuropsychiatric disorders [84][85][86]. However, only few fNIRS studies focusing on its utility in predicting rTMS treatment response in patients with MDD have been published.…”

Section: Biomarkers That Predict Response To Rtms/tbs Treatment Neuroimaging Correlates and Predictors Of Treatment Responsesmentioning

confidence: 99%

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity

Chou

Lin

et al. 2021

Clin Psychopharmacol Neurosci

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Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.

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Perceived Occupational Stress is associated with Decreased Cortical Activity of the Prefrontal Cortex: A Multichannel Near-infrared Spectroscopy Study

Cited by 29 publications

References 59 publications

Amygdala and prefrontal cortex activity varies with individual differences in the emotional response to psychosocial stress.

Amygdala and prefrontal cortex activity varies with individual differences in the emotional response to psychosocial stress.

The slope of cerebral oxyhemoglobin oscillation is associated with vascular reserve capacity in large artery steno-occlusion

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity

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