Background: The heavy work load and pressure to which nursing professionals are subjected leads to an increase in stress-related problems, such as burnout. Personal resources, such as job crafting, proactive personality, self-efficacy and regulatory focus are fundamental in palliating negative effects in the work environment.Objective: To analyze individual differences, with attention to proactive personality, regulatory approach and general self-efficacy in job crafting, and to determine the predictive power of these variables for burnout in nursing professionals. Methods: The sample was made up of 643 nurses. After correlation and descriptive analyses, multiple linear regression models were computed to find out the possible predictor role of the individual variables on burnout. Main Outcome Measures were: Proactive personality, Regulatory focus, Self-efficacy (participant beliefs concerning their ability to handle different daily situations adequately), Job Crafting behavior and Burnout.Results: The results showed that job crafting, proactive personality, general self-efficacy and the promotion regulatory focus were associated with a decrease in burnout in healthcare workers. Similarly, the predictive models for each of the factors in burnout in all cases included the increase in structural resources dimension of job crafting as the variable with the most weight. Furthermore, the increase in the social resources of Job Crafting for the social climate of the Burnout acted as mediator of this relationship.Conclusion: Job Crafting has been shown to be a variable promoting positive changes in the work environment that acts as a predictor of employee Burnout levels.