Perceived Social Support and Interpersonal Functioning as Predictors of Treatment Response Among Depressed Older Adults

Woods, Alexandra; Solomonov, Nili; Liles, Brian; Guillod, Arielle; Kales, Helen C.; Sirey, Jo Anne

doi:10.1016/j.jagp.2020.12.021

Cited by 21 publications

(5 citation statements)

References 46 publications

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“…Altered processing of social touch might blunt the drive to seek physical closeness or even result in an avoidance of interpersonal touch, which could negatively affect sexuality and the overall satisfaction in romantic relationships (Bell, Daly, & Gonzalez, 1987;Gulledge, Gulledge, & Stahmannn, 2003;Muise, Giang, & Impett, 2014). Eventually, this might lead to separation, which is again a predictor for worse illness trajectories (Law & Sbarra, 2009;Woods et al, 2021) and increased risk for suicidal behaviors (Calati et al, 2019).…”

Section: Discussion/conclusionmentioning

confidence: 99%

Altered reward network responses to social touch in major depression

et al. 2023

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Background Social touch is an integral part of social relationships and has been associated with reward. Major depressive disorder (MDD) is characterized by severe impairments in reward processing, but the neural effects of social touch in MDD are still elusive. In this study, we aimed to determine whether the neural processing of social touch is altered in MDD and to assess the impact of antidepressant therapy. Methods Before and after antidepressant treatment, 53 MDD patients and 41 healthy controls underwent functional magnetic resonance imaging (fMRI) while receiving social touch. We compared neural responses to social touch in the reward network, behavioral ratings of touch comfort and general aversion to interpersonal touch in patients to controls. Additionally, we examined the effect of treatment response on those measures. Results Clinical symptoms decreased after treatment and 43.4% of patients were classified as responders. Patients reported higher aversion to interpersonal touch and lower comfort ratings during the fMRI paradigm than controls. Patients showed reduced responses to social touch in the nucleus accumbens, caudate nucleus and putamen than controls, both before and after treatment. Contrary to our hypotheses, these effects were independent of touch velocity. Non-responders exhibited blunted response in the caudate nucleus and the insula compared to responders, again irrespective of time. Conclusions These findings suggest altered striatal processing of social touch in MDD. Persistent dysfunctional processing of social touch despite clinical improvements may constitute a latent risk factor for social withdrawal and isolation.

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Section: Discussion/conclusionmentioning

confidence: 99%

Altered reward network responses to social touch in major depression

et al. 2023

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“…Consistent with previous studies ( 21 , 43 ), social support negatively affected depression. One study reported that high perceived social support predicted reduced depression severity ( 44 ). Older adults with a higher level of social support were more likely to feel the support and interaction of family and individuals and thus had a lower depression tendency.…”

Section: Discussionmentioning

confidence: 99%

The relationship between living arrangements and depression among older adults in Shandong, China: The mediating role of social support

Pei

Hu²,

Qin³

et al. 2022

Front. Psychiatry

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BackgroundLiving arrangements and social support have an impact on depression among older adults. However, the underlying mechanism between those variables remains unknown. This study aims to investigate the mediating role of social support in the relationship between living arrangements and depression among older adults.Materials and methodsMulti-stage stratified sampling method was used to select 3,859 older adults from Taian City, Shandong Province, China, for cross-sectional investigation. Living arrangements were measured by a question. Social support and depression were measured using the Multidimensional Scale of Perceived Social Support and Patient Health Questionnaire-9. Multiple linear regression models were used to assess the relationship between living arrangements and depression and the possible influence of social support on the relationship between living arrangements and depression.ResultsStatistics showed that 15.08% of older adults lived alone. After controlling for covariates, living arrangements (ß = 0.45, t = 2.87, P < 0.01) and social support (ß =−0.08, t =−16.93, P < 0.001) were significantly associated with depression. The linear regression model showed that social support mediated the relationship between living arrangements and depression, and the mediating effect accounted for 18.20% of the total effect.ConclusionThis study revealed that living arrangements played an essential role in indirectly predicting depression in older adults through social support. This provided evidence for how to reduce depression in older adults.

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“…Impaired touch-associated reward might blunt the drive to seek physical closeness or even result in an avoidance of interpersonal touch, which could negatively affect sexuality and the overall satisfaction in romantic relationships [63–65]. Eventually, this might lead to separation, which is again a predictor for worse illness trajectories [66,67] and increased risk for suicidal behaviors [60].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Altered reward network responses to social touch in major depression

Mielacher

Scheele

Kiebs

et al. 2021

Preprint

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IntroductionAffective touch is highly rewarding and an integral part of social relationships. Major depressive disorder (MDD) is characterized by severe impairments in reward processing, but the neural effects of social touch in MDD are still elusive.ObjectiveWe aimed to determine whether the neural processing of social touch is impaired in MDD and to assess the impact of antidepressant therapy.MethodsBefore and after antidepressant treatment, 53 MDD patients and 41 healthy controls underwent functional magnetic resonance imaging (fMRI) while receiving social touch. We compared neural responses to social touch in the reward network, behavioral ratings of touch comfort and general aversion to interpersonal touch in MDD patients to controls. Additionally, we examined the effect of treatment response on those measures.ResultsClinical symptoms decreased after treatment and 43.4% of patients were classified as responders. Patients reported higher aversion to social touch and lower comfort ratings during the fMRI paradigm than controls. Patients showed reduced responses to social touch in the nucleus accumbens, caudate nucleus and putamen than controls, both before and after treatment. Non-responders exhibited blunted response in the caudate nucleus and the insula compared to responders, again irrespective of treatment.ConclusionsThese findings confirm our hypothesis that interpersonal touch as an indicator of social reward processing is impaired in MDD. Persistent dysfunctional processing of social touch despite clinical improvements may constitute a latent risk factor for social withdrawal and isolation. New treatment approaches are necessary to specifically target social reward processing and disturbed body awareness in MDD.

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Perceived Social Support and Interpersonal Functioning as Predictors of Treatment Response Among Depressed Older Adults

Cited by 21 publications

References 46 publications

Altered reward network responses to social touch in major depression

Altered reward network responses to social touch in major depression

The relationship between living arrangements and depression among older adults in Shandong, China: The mediating role of social support

Altered reward network responses to social touch in major depression

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