The terms “stress” or “stressor” usually refer to situations, demands, or burdens that require individuals to adapt their behavior, while stress response is the heightened bodily reaction to perceived stress. As stress accumulates, individuals’ abilities to cope can become overtaxed, depleting mind–body resources and increasing the probability of poor health. Stress outcomes of concern to health researchers span the realms of mental health, physical health and functioning, mortality, and biomarkers. Research shows that the impact of stress is large, affecting body chemistry, the functioning of organ systems, mental and physical health, and ultimately risk for mortality.