Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume

Grupe, Dan; Barnes, Alexandra L; Gresham, Lauren K.; Kirvin-Quamme, Andrew; Nord, Elizabeth; Alexander, Andrew L.; Abercrombie, Heather C.; Schaefer, Stacey M.; Davidson, Richard J.

doi:10.1016/j.ynstr.2022.100469

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…This lack of a direct relationship between the size of the hippocampal subfields and PS function is also seen in our study with patients with MTLE. Recently, Grupe et al ( 71 ) did not find a hypothesized correlation between DG/CA3 volume and behavioral pattern separation measures. Furthermore, our results are also extended to the microstructure parameters, concluding that the damage of one specific hippocampal part or the alteration of certain diffusion parameters cannot, on their own, explain the impairment that these patients present when performing pattern separation.…”

Section: Discussionmentioning

confidence: 95%

Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination

Garcia-Munoz

Alemán‐Gómez²,

Toledano³

et al. 2023

Front. Neurol.

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IntroductionPattern separation (PS) is a fundamental aspect of memory creation that defines the ability to transform similar memory representations into distinct ones, so they do not overlap when storing and retrieving them. Experimental evidence in animal models and the study of other human pathologies have demonstrated the role of the hippocampus in PS, in particular of the dentate gyrus (DG) and CA3. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HE) commonly report mnemonic deficits that have been associated with failures in PS. However, the link between these impairments and the integrity of the hippocampal subfields in these patients has not yet been determined. The aim of this work is to explore the association between the ability to perform mnemonic functions and the integrity of hippocampal CA1, CA3, and DG in patients with unilateral MTLE-HE.MethodTo reach this goal we evaluated the memory of patients with an improved object mnemonic similarity test. We then analyzed the hippocampal complex structural and microstructural integrity using diffusion weighted imaging.ResultsOur results indicate that patients with unilateral MTLE-HE present alterations in both volume and microstructural properties at the level of the hippocampal subfields DG, CA1, CA3, and the subiculum, that sometimes depend on the lateralization of their epileptic focus. However, none of the specific changes was found to be directly related to the performance of the patients in a pattern separation task, which might indicate a contribution of various alterations to the mnemonic deficits or the key contribution of other structures to the function.Discussionwe established for the first time the alterations in both the volume and the microstructure at the level of the hippocampal subfields in a group of unilateral MTLE patients. We observed that these changes are greater in the DG and CA1 at the macrostructural level, and in CA3 and CA1 in the microstructural level. None of these changes had a direct relation to the performance of the patients in a pattern separation task, which suggests a contribution of various alterations to the loss of function.

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Section: Discussionmentioning

confidence: 95%

Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination

Garcia-Munoz

Alemán‐Gómez²,

Toledano³

et al. 2023

Front. Neurol.

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“…We showed that the BIS was significantly associated with higher right hippocampus laterality, which is dependent on the ratio of volumetric hemispheric difference, and may vary at extreme values. For instance, greater right hippocampus laterality has been associated with healthy brains and better cognition (Grupe et al., 2022; Milne et al., 2018; Woolard & Heckers, 2012), yet it appears that marked right hippocampus laterality is a predictor of cognitive impairment, possibly driven by volume loss in the left hippocampus due to its greater sensitivity to the neurotoxic effects of stress (Cherbuin et al., 2010; Grupe et al., 2022). LI measures will be useful in future studies of the revised RST, but thoughtful interpretation is required.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of the revised reinforcement sensitivity theory: A cross‐sectional structural neuroimaging study in middle‐aged adults

Espinoza Oyarce,

Burns,

Shaw

et al. 2024

Psychophysiology

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The revised reinforcement sensitivity theory (RST) proposes that neurobiological systems control behavior: the fight‐flight‐freeze (FFFS) for avoidance of threat; behavioral approach/activation (BAS) for approach to rewards; and behavioral inhibition (BIS) for conflict resolution when avoidance and approach are possible. Neuroimaging studies have confirmed some theoretical associations between brain structures and the BAS and BIS; however, little representative population data are available for the FFFS. We investigated the neural correlates of the revised RST in a sample of 404 middle‐aged adults (Mage = 47.18 (SD = 1.38); 54.5% female). Participants underwent structural magnetic resonance imaging and completed health questionnaires and the BIS/BAS/FFFS scales. We used multiple regression analyses to investigate the association between scale scores and volumes of a priori theoretically linked regions of interest while controlling for sex, age, intracranial volume, and cardio‐metabolic variables; and conducted exploratory analyses on cortical thickness. The BIS was negatively associated with hippocampus laterality. At standard significance levels, the fear component of the FFFS was positively associated with anterior cingulate cortex; the BAS was positively associated with bilateral caudate; and the BIS was positively associated with posterior cingulate cortex volume. Furthermore, these neurobiological systems showed distinct patterns of association with cortical thickness though future work is needed. Our results showed that the neurobiological systems of the revised RST characterized in rodents can also be identified in the human brain.

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Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors

Joss,

Teicher,

Lazar

2024

Journal of Affective Disorders Reports

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Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume

Cited by 3 publications

References 69 publications

Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination

Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination

Neural correlates of the revised reinforcement sensitivity theory: A cross‐sectional structural neuroimaging study in middle‐aged adults

Beneficial effects of mindfulness-based intervention on hippocampal volumes and episodic memory for childhood adversity survivors

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