Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

Danilescu, Claudia Monica; Ionescu, Mihaela; Săndulescu, Larisa; Pîrlog, Mihail Cristian; Streba, Costin Teodor; Rogoveanu, Ion

doi:10.3390/diagnostics12051177

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Surprisingly, DT scores increased post-DAA in this study compared to a reduction in a prospective study with 90 HCV-monoinfected participants [40]. Nonetheless, the median DT score at the post-DAA visit remained well below the commonly referred cutoff score (≥ 4), which signi es distress with clinical signi cance [41].…”

Section: Neurological and Neuropsychiatric Outcomescontrasting

confidence: 70%

Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand

Ocampo,

Sacdalan,

Pinyakorn

et al. 2024

Preprint

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Background Hepatitis C virus (HCV) coinfection may further compromise immunological and cognitive function in people with HIV (PWH). This study compared laboratory and neuropsychiatric measures across the periods of HCV seroconversion and direct-acting antiviral (DAA) therapy with sustained virologic response (SVR) among PWH who initiated antiretroviral therapy (ART) during acute HIV infection (AHI) and acquired HCV after 24 weeks of ART. Methods Participants from the RV254 AHI cohort underwent paired laboratory and neuropsychiatric assessments during regular follow-up. The former included measurements of CD4 + and CD8 + T-cell counts, HIV RNA, liver enzymes, and lipid profiles. The latter included the Patient Health Questionnaire-9 (PHQ-9), Distress Thermometer (DT), and a 4-test cognitive battery that evaluated psychomotor speed, executive function, fine motor speed and dexterity. The raw scores in the battery were standardized and averaged to create an overall performance (NPZ-4) score. Parameters of HCV-coinfected participants were compared across HCV seroconversion and DAA treatment groups. Results Between 2009 and 2022, 79 of 703 RV254 participants acquired HCV after ≥ 24 weeks of ART; 53 received DAA, and 50 (94%) achieved SVR. All participants were Thai males (median age: 30 years); 34 (68%) denied past intravenous drug use, and 41 (82%) had a history of other sexually transmitted infections during follow-up. Following SVR, aspartate transferase (AST) and alanine transaminase (ALT) decreased (p < 0.001), while total cholesterol, low-density lipoprotein, and triglycerides increased (p < 0.01). The median CD4+/CD8 + ratio increased from 0.91 to 0.97 (p = 0.012). NPZ-4 improved from 0.75 to 0.91 (p = 0.004). The median DT score increased from 1.7 to 2.7 (p = 0.045), but the PHQ-9 score remained unchanged. Conclusion HCV coinfection is common in this group of high-risk PWH, highlighting the need for regular screening, early diagnosis, and treatment. There was a modest improvement in the CD4+/CD8 + T-cell ratio and cognitive performance after DAA therapy in patients who achieved SVR. Future studies should examine potential neuropsychiatric impacts during early HCV infection as well as the longer-term neuropsychiatric outcomes after DAA treatment with SVR.

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Section: Neurological and Neuropsychiatric Outcomescontrasting

confidence: 70%

Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand

Ocampo,

Sacdalan,

Pinyakorn

et al. 2024

Preprint

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“…The source of stress may be physical complaints related with the disease and using drugs. In patients with hepatitis C responses to stress depend on individual personality traits, on mechanisms for coping with stress [6,7]. According to Papadimitriou the approach to patients with hepatitis C should be of a holistic character and consider biological, psychological, and social aspects of life, because this group of patients suffer as a whole [8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of coping with illness among patients with hepatitis C – on example of research in Poland

Sierpińska

2023

J Educ Health Sport

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Introduction: In Poland approximately 2% of the population are infected with HCV. The majority (70-80%) of persons infected with HCV develop chronic hepatitis C which, when untreated, may lead to cirrhosis and/or hepatocellular carcinoma. The skills of coping with stress and acceptance of chronic illness may motivate patients for participation in treatment and leading a health-promoting life style. Objective: The aim of the study was assessment of coping with illness in patients with chronic hepatitis C. Materials and Method: The study included 220 adults with chronic hepatitis C, and was conducted by the method of a diagnostic survey using the Polish questionnaire: Brief Method of Assessment of Coping with Illness (Krótka Metoda Oceny Radzenia Sobie z Chorobą - KMORSZCH), the Acceptance of Illness Scale (AIS), and an author-constructed questionnaire. Results: The examined group of patients with hepatitis C most strongly presented style oriented on emotions and passivity (mean score 1.20), and style focused on problem solving (mean score 1.05), followed by respondents who presented avoidance-oriented style (mean score 0.98), whereas the style focused on seeking the best solution to the problem was most rarely chosen (mean score 0.77). It was found that the more frequently the respondents presented style oriented on experiencing emotions and passivity, to the significantly lower degree they accepted their illness. Patients with higher education significantly more often presented style focused on seeking the best solution to the problem (p<0.045),while those with the lowest level of education significantly more frequently were oriented on experiencing emotions and passivity (p<0.001). Rural inhabitants significantly more often presented style oriented on experiencing emotions and passivity (p<0.002). The remaining independent variables: gender, age, marital status, number of years of illness, and occupational activity had an insignificant effect on the selection of the style of coping with hepatitis C. Conclusions: The results of the study confirm the need for psychotherapeutic actions with respect to patients with hepatitis C in order to help them cope with the chronic disease, because they most often chose style oriented on emotions and passivity. Psychological assistance should be provided especially for the group of patients who have difficulty with acceptance of the illness.

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“…DAAs are combinations of medications that are currently being used to effectively treat hepatitis C [29]. Although effective, the therapy has its own shortcomings; (i) The cost of DAAs is quite high, adding to the economic burden on patients [30], and there is at least one report of perceived stress in HCV infected patient under DAA therapy [31], (ii) there have been reports of associated side effects [32,33], (iii) not all HCV genotypic variants are equally responsive to the current therapy [34], (iv) resistance-related variants could arise during DAA monotherapy as a result of the high HCV mutation rate [35,36], (iv) failed therapies have been reported for some di cult-to-treat patients [37], and (v) recurrences of hepatocellular carcinoma have been reported after HCV therapy with DAAs [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of interactions between the hepatitis C virus NS3/4A and sulfonamidobenzamide based molecules using molecular docking, molecular dynamics simulations and binding free energy calculations

Ren

Vaid

Lee

et al. 2022

J Comput Aided Mol Des

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The Hepatitis C Virus (HCV) NS3/4A is an attractive target for the treatment of Hepatitis C infection.Herein, we present an investigation of HCV NS3/4A inhibitors based on a sulfonamidobenzamide scaffold. Inhibitor interactions with HCV NS3/4A were explored by molecular docking, molecular dynamics simulations, and MM/PBSA binding free energy calculations. All of the inhibitors adopt similar molecular docking poses in the catalytic site of the protease that are stabilized by hydrogen bond interactions with G137 and the catalytic S139, which are known to be important for potency and binding stability. The quantitative assessments of binding free energies from MM/PBSA correlate well with the experimental results, with a high coe cient of determination, R 2 of 0.92. Binding free energy decomposition analyses elucidate the different contributions of Q41,

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Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

Cited by 5 publications

References 41 publications

Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand

Neuropsychiatric and Laboratory Outcomes of Hepatitis C Treatment in an Early-Treated HIV Cohort in Thailand

Assessment of coping with illness among patients with hepatitis C – on example of research in Poland

Evaluation of interactions between the hepatitis C virus NS3/4A and sulfonamidobenzamide based molecules using molecular docking, molecular dynamics simulations and binding free energy calculations

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